THE MUSCULOSKELETAL MANIFESTATIONS OF CYSTIC-FIBROSIS
THE MUSCULOSKELETAL MANIFESTATIONS OF CYSTIC-FIBROSIS
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DOI：
10.1016/0049-0172(86)90018-1
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发表时间：
1986-02-01
影响因子：
5
通讯作者：
LEVISON, H
中科院分区：
文献类型：
--
作者：
RUSH, PJ;SHORE, A;LEVISON, H
对27例CF和关节投诉患者进行了审查。12名患者有关节炎，11名有HPO，4名有机械性颈部和背部疼痛症状。我们已经证实了CF与关节炎的发作形式的关联。我们首次报道了这些患者中的一个亚组后来发展为持续性滑膜炎，并伴有进行性不对称、糜烂性疾病。CF关节炎的病因尚不清楚，但可能与慢性感染和免疫复合物机制有关。CF关节炎可以与CF诱导的HPO形成对比，后者与更严重的肺部疾病、男性优势和更大的平均症状发作年龄相关。机械性颈部和背部疼痛可能与CF相关的脊柱侧凸或脊柱后凸有关。
Twenty-seven patients with CF and joint complaints were reviewed. Twelve patients had arthritis, 11 had HPO, and four had symptoms of mechanical neck and back pain. We have confirmed the association of CF with an episodic form of arthritis. For the first time, we have reported that a subgroup of these patients later develop persistent synovitis with progressive asymmetric, erosive disease. The etiology of CF arthritis is unclear, but may relate to chronic infection and immune complex mechanisms. CF arthritis can be contrasted with CF induced HPO, which is associated with worse lung disease, a male predominance, and an older mean age of onset of symptoms. Mechanical neck and back pain may relate to an associated scoliosis or kyphosis in CF.