Carcinogenicity of potassium bromate administered in the drinking water to male B6C3F1 mice and F344/N rats
Carcinogenicity of potassium bromate administered in the drinking water to male B6C3F1 mice and F344/N rats
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DOI：
10.1177/019262339802600501
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发表时间：
1998-09-01
影响因子：
1.5
通讯作者：
Wolf, DC
中科院分区：
文献类型：
--
作者：
DeAngelo, AB;George, MH;Wolf, DC
臭氧已被提议用于水消毒，因为它比氯更有效地杀死微生物，并且比氯化导致更低水平的致癌三卤甲烷。臭氧在高溴含量的地表沃茨中导致次溴酸的形成，并形成溴化有机副产物和溴酸盐。在雄性B6 C3 F（1）小鼠和F344/N大鼠中研究了溴酸钾（KBrO 3）的致癌性和慢性毒性，以证实和扩展先前工作的结果。小鼠在饮用水中用0、0.08、0.4或0.8 g/L KBrO 3处理长达100周，大鼠用0、0.02、0.1、0.2或0.4 g/L KBrO 3处理。对动物实施安乐死、尸检，并进行完整的肉眼检查。通过常规方法处理选定的组织和大体病变，进行光学显微镜检查。目前的研究表明，KBrO 3是致癌性的大鼠肾脏，甲状腺和间皮瘤，是一种肾致癌物质在雄性小鼠。溴酸钾在水浓度低至0.02 g/L（20 ppm; 1.5 mg/kg/天）时对啮齿动物具有致癌性。这些数据可用于估计与饮用水消毒从氯化改为臭氧化有关的人类健康风险。
Ozone has been proposed for water disinfection because it is more efficient than chlorine for killing microbes and results in much lower levels of carcinogenic trihalomethanes than does chlorination. Ozone leads to formation of hypobromous acid in surface waters with high bromine content and forms brominated organic by-products and bromate. The carcinogenicity and chronic toxicity of potassium bromate (KBrO3) was studied in male B6C3F(1) mice and F344/N rats to confirm and extend the results of previous work. Mice were treated with 0, 0.08, 0.4, or 0.8 g/L KBrO3 in the drinking water for up to 100 wk, and rats were provided with 0, 0.02, 0.1, 0.2, or 0.4 g/L KBrO3. Animals were euthanatized, necropsied, and subjected to a complete macroscopic examination. Selected tissues and gross lesions were processed by routine methods for light microscopic examination. The present study showed that KBrO3 is carcinogenic in the rat kidney, thyroid, and mesothelium and is a renal carcinogen in the male mouse. KBrO3 was carcinogenic in rodents at water concentrations as low as 0.02 g/L (20 ppm; 1.5 mg/kg/day). These data can be used to estimate the human health risk that would be associated with changing from chlorination to ozonation for disinfection of drinking water.