Tear film, contact lens, and patient-related factors associated with contact lens-related dry eye
Tear film, contact lens, and patient-related factors associated with contact lens-related dry eye
复制标题
DOI：
10.1167/iovs.05-1392
复制
发表时间：
2006-04-01
影响因子：
4.4
通讯作者：
Sinnott, LT
中科院分区：
文献类型：
--
作者：
Nichols, JJ;Sinnott, LT
目的。检查泪膜、隐形眼镜、医疗和患者相关因素与自我报告的隐形眼镜相关性干眼相关。方法：415名隐形眼镜佩戴者被招募参加这一阶段的更大规模的横断面研究。各种泪膜(如干涉仪、渗透压、苯酚红线、核磁共振、荧光素和李萨明绿染色)、隐形眼镜(即水分、折射率、材料)和与患者相关的因素(如性别、社会人口、教育、收入和医疗健康)与干眼状况有关。采用单变量和多变量Logistic回归模型分析泪膜、隐形眼镜和患者相关因素与干眼症的关系。结果：在415名受试者中，360人的数据被用于分析。平均年龄为31.1+/-11.5岁，245名(68%)为女性，55.3%的人通过自我报告被归类为与隐形眼镜相关的干眼。总体而言，水凝胶镜片配戴者327人(90.8%)，透气镜片配戴者33人(9.2%)。多因素分析显示，女性(P=0.007)、镜片名义含水率较高(P=0.002)、晶状体前泪膜快速变薄时间(P=0.008)、频繁使用非处方药止痛药(P=0.02)、角膜缘注射(P=0.03)、泪膜渗透压升高(P=0.008)等因素与干眼状态有关。其他因素包括使用高含水率镜片，传统上有报道称，与低含水率镜片相比，高含水率镜片的患者舒适度较低，可能是由于变质和沉积。正如其他干眼研究发现的那样，女性比男性更有可能报告与隐形眼镜相关的干眼。
PURPOSE. To examine tear film, contact lens, medical, and patient-related factors associated with self-reported contact lens-related dry eye.METHODS. Four hundred fifteen contact lens wearers were recruited and enrolled in this phase of a larger cross-sectional study. A variety of tear film (e.g., interferometry, osmolality, phenol red thread, meibography, fluorescein, and lissamine green staining), contact lens (i.e., water content, refractive index, material), and patient-related (e.g., gender, sociodemographic, education, income, and medical health) factors were examined in relation to dry eye status. Univariate and multivariate logistic regression models were used to examine the relation between these tear film, contact lens, and patient-related factors associated with dry eye status.RESULTS. Of the 415 enrolled, the data from 360 were Used in the analyses. The average age was 31.1 +/- 11.5 years, 245 (68%) participants were female, and 55.3% were classified as having-contact lens-related dry eye via self-report. Overall, 327 (90.8%) were hydrogel lens wearers and 33 (9.2%) were gas-permeable lens wearers. Several factors were shown to be related to dry eye status in multivariate modeling, including female gender (P = 0.007), lenses with higher nominal water content (P = 0.002), rapid prelens tear film thinning time (P = 0.008), frequent Usage of over-the-counter pain medication (P = 0.02), limbal injection (P = 0.03), and increased tear film osmolality (P = 0.05).CONCLUSIONS. Contact lens-related dry eye may be explained mechanistically by increased tear film thinning times (evaporation or dewetting) resulting in increased tear film osmolality. Other contributing factors include the use of high-water-content lenses, which have traditionally been reported to be associated with less patient comfort than lower-water-content lenses, potentially due to spoilation and deposition. As found in other studies of dry eye, women are more likely to report contact lens-related dry eye than are men.