The Hereditary Factor in Arterial Blood-pressure
The Hereditary Factor in Arterial Blood-pressure
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动脉血压的遗传因素
DOI：
10.1136/bmj.1.5323.75
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发表时间：
1963
影响因子：
--
通讯作者：
P. D. Oldham
中科院分区：
文献类型：
--
作者：
W. Miall;P. D. Oldham
目前关于原发性高血压本质的观点冲突反映了我们对普通人群动脉压的无知。虽然可靠的血压间接测量仪器已经存在了超过半个世纪，但我们仍然不知道动脉压是如何随着年龄的增长而增加的;我们对环境因素的影响知之甚少，并且对高血压的遗传模式存在分歧。对这些问题的调查不容易从医院实践中开始，而且似乎很有可能通过现代流行病学技术对代表性人群的长期研究将在未来十年内对了解影响血压的因素做出很大贡献。在南威尔士正在进行两项这样的长期流行病学研究，本报告概述了对从这些研究中获得的遗传数据的分析。其他论文将讨论环境和个人因素的影响。这里报告的结果包括从最初的“横断面“调查和四年后进行的后续调查中得出的数据。其中一些数据以前已经发表过（Miall和奥尔德姆，1955年，1957年，1958年; Miall，1962年），但
The current conflict of views about the nature of essential hypertension reflects our ignorance of arterial pressure in the general population. Though reliable apparatus for the indirect measurement of bloodpressure has been available for over half a century we still do not know how arterial pressure increases with age in the population at large; we know little of the influence of environmental factors and there is disagreement about the mode of inheritance of hypertension. Investigations of these questions cannot easily be initiated from hospital practice, and it seems highly probable that the long-term study of representative populations by the modern techniques of epidemiology will contribute much to the understanding of the factors affecting blood-pressure within the next decade. Two such long-term epidemiological studies are in progress in South Wales, and this report summarizes the analyses of the genetic data derived from them. Other papers will deal with the influence of environmental and personal factors. The results reported here include data derived from the original " cross-sectional " surveys, and from the follow-up surveys which were undertaken four years later. Some of these data have been published previously (Miall and Oldham, 1955, 1957, 1958; Miall, 1962), but