Psychological stress and antibody response to immunization: A critical review of the human literature
Psychological stress and antibody response to immunization: A critical review of the human literature
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DOI：
10.1097/00006842-200101000-00002
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发表时间：
2001-01-01
影响因子：
3.3
通讯作者：
Rabin, BS
中科院分区：
文献类型：
--
作者：
Cohen, S;Miller, GE;Rabin, BS
目的：本综述的目的是评估心理应激影响人类免疫抗体应答的假说的证据。方法：对相关文献进行回顾性分析。结果：有证据支持心理应激和免疫抑制体液免疫（抗体）反应之间的关联。这种关联在继发性免疫应答的情况下是令人信服的，但对于原发性应答是弱的。缺乏与初次应答相关的一致证据可能是由于未能考虑在抗体产生过程中需要提高应激时的关键点。在长期高水平压力（严重持久的问题或高水平的特质负面影响）的患者中发现了较低的二级抗体反应。这些反应在老年人中最为一致。较低的次级反应也被发现为那些报告急性应激或负面影响，但只有在分泌型免疫球蛋白A抗体的研究中，心理和抗体措施在时间上非常密切相关。健康的做法并没有调解压力和抗体反应之间的关系，但是，有迹象表明，应激患者中皮质醇水平升高可能发挥作用。证据还表明，可能的影响，性格的压力反应性和低积极的影响，抑制抗体的产生。结论：文献支持心理压力和免疫接种的抗体反应之间的关系。在次要缓解的情况下，数据令人信服，但对于主要缓解，数据较弱。在未来的研究中，需要更多地关注应激和抗体反应的动力学及其相互关系。
Objective: The objective of this review was to evaluate the evidence for the hypothesis that psychological stress influences antibody response to immunization in humans. Methods: A critical review of the literature was conducted. Results: The evidence supports an association between psychological stress and suppression of humoral immune (antibody) response to immunization. This association is convincing in the case of secondary immune response but weak for primary response. The lack of consistent evidence for a relation with primary response may be attributed to a failure to consider the critical points when stress needs to be elevated in the course of the production of antibody. Lower secondary antibody responses were found among patients with chronically high levels of stress (severe enduring problems or high levels of trait negative affect). These responses were found most consistently among older adults. Lower secondary responses were also found for those reporting acute stress or negative affect, but only in studies of secretory immunoglobulin A antibody in which psychological and antibody measures were linked very closely in time. Health practices did not mediate relations between stress and antibody responses; however, there were indications that elevated cortisol levels among stressed patients could play a role. Evidence also suggests the possible influences of dispositional stress-reactivity and low positive affect in the inhibition of antibody production. Conclusions: The literature supports a relationship between psychological stress and antibody responses to immunizations. The data are convincing in the case of secondary response but weak for primary response. More attention to the kinetics of stress and antibody response and their interrelations is needed in future research.