STRAIN-A/J MOUSE LUNG ADENOMA GROWTH-PATTERNS VARY WHEN INDUCED BY DIFFERENT CARCINOGENS
STRAIN-A/J MOUSE LUNG ADENOMA GROWTH-PATTERNS VARY WHEN INDUCED BY DIFFERENT CARCINOGENS
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DOI：
10.1177/019262339101900212
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发表时间：
1991-01-01
影响因子：
1.5
通讯作者：
STONER, GD
中科院分区：
文献类型：
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作者：
GUNNING, WT;CASTONGUAY, A;STONER, GD
小鼠肺腺瘤的组织发生目前正在几个实验室进行研究。基于对不同品系小鼠数量有限的致癌物的研究，一些研究人员提出，小鼠的所有肺腺瘤都来自肺泡II型细胞，而另一些研究人员则认为大多数肿瘤来自Clara细胞。这份报告与以前的研究不同，因为12种不同的致癌物被评估了它们在单一品系小鼠(品系A小鼠)中诱导的肺肿瘤生长模式的类型。致癌物黄曲霉毒素B1、苯并(A)芘、1，2-二甲基肼、3-甲基胆蒽、4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone和N-亚硝基甲基脲诱导的肿瘤以固体/肺泡生长为主，而N-亚硝基二乙胺诱导的肿瘤以乳头状瘤为主。大多数其他致癌物诱发的实体/肺泡生长模式的肺癌比例高于乳头状生长模式，但两种生长模式之间的比例不同。如果像其他人建议的那样，实体瘤来自肺泡型II型细胞，乳头状瘤来自Clara细胞，那么致癌物可能在它们转化一种或另一种细胞类型的能力方面有所不同。
The histogenesis of mouse lung adenomas is currently being investigated in several laboratories. Based upon studies of a limited number of carcinogens in different mouse strains, some investigators suggest that all lung adenomas in mice are derived from alveolar type II cells, whereas others suggest a Clara cell origin for a majority of the tumors. This report differs from previous investigations in that 12 different carcinogens were evaluated for the types of lung tumor growth patterns they induced in a single mouse strain (strain A mice). The carcinogens aflatoxin B1 (AFB1), benzo(a)pyrene (BP), 1,2-dimethylhydrazine (DMH), 3-methylcholanthrene (MCA), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and N-nitrosomethylurea (MNU) induced tumors with a predominately solid/alveolar growth pattern, whereas N-nitrosodiethylamine (NDEA) induced predominantly papillary tumors. Most of the other carcinogens induced a higher proportion of lung tumors with the solid/alveolar growth pattern than with the papillary growth pattern; however, ratios between the 2 growth patterns varied. If, as suggested by others, solid tumors are derived from alveolar type II cells and papillary tumors from Clara cells, then carcinogens may differ with respect to their ability to transform one cell type or the other.