Alterations in brain metabolism during the first year of HIV infection
Alterations in brain metabolism during the first year of HIV infection
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DOI：
10.1007/s13365-011-0030-9
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发表时间：
2011-06-01
影响因子：
3.2
通讯作者：
Gonzalez, R. G.
中科院分区：
文献类型：
--
作者：
Lentz, Margaret R.;Kim, Woong-Ki;Gonzalez, R. G.
在急性HIV感染期间，未感染和感染的单核细胞向大脑的迁移可能会引发代谢变化，这可以用磁共振波谱（MRS）观察到。在此，我们测量了艾滋病毒感染第一年脑代谢的变化，并检查了这些代谢物水平与血液中测量的CD16+单核细胞群的关系。对9例急性HIV感染期间发现的HIV阳性受试者和9例血清阴性对照进行MRS检测。在不确定的Western blot后90天内对HIV阳性受试者进行检查，然后在2个月和6个月后，在早期感染期间再次进行检查。采集血样进行血浆病毒RNA和单核细胞亚群定量。HIV阳性受试者被确定为急性病毒性疾病，没有表现出严重的认知缺陷，如痴呆或轻微的认知运动障碍。在HIV感染的最初一年中，观察到额叶皮层和白质的脂膜代谢（胆碱水平）的变化。大量CD16+单核细胞与大脑中较低的n -乙酰天冬氨酸水平和较高的胆碱水平相关。这些结果表明，HIV感染在感染早期诱导了大脑的代谢变化，这些变化可能与周围的单核细胞动力学有关。
Migration of both uninfected and infected monocytes into the brain during acute HIV infection likely initiates metabolic changes that can be observed with magnetic resonance spectroscopy (MRS). Herein, we measured changes in brain metabolism during the first year of HIV infection and examined the relationship of these metabolite levels to CD16+ monocyte populations measured in the blood. MRS was performed on nine HIV+ subjects identified during acute HIV infection and nine seronegative control subjects. HIV+ subjects were examined within 90 days of an indeterminate Western blot, then again 2 and 6 months later, during early infection. Blood samples were collected for plasma viral RNA and monocyte subset quantification. HIV+ subjects were identified with acute viral ailment and did not display severe cognitive deficits such as dementia or minor cognitive motor disorder. Changes in lipid membrane metabolism (choline levels) in the frontal cortex and white matter were observed during the initial year of HIV infection. Greater numbers of CD16+ monocytes were associated with lower N-acetylaspartate levels and higher choline levels in the brain. These results suggest that HIV infection induces metabolic changes in the brain early during infection and that these changes may be related to monocyte dynamics in the periphery.