Molecular structures and function of the autophagosome-lysosome fusion machinery.
Molecular structures and function of the autophagosome-lysosome fusion machinery.
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自噬体-溶酶体融合机制的分子结构与功能。
DOI：
10.1080/27694127.2024.2305594
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发表时间：
2024-02
期刊：
影响因子：
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通讯作者：
Jiajie Diao;Calvin K Yip;Qing Zhong
中科院分区：
文献类型：
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作者：
Jiajie Diao;Calvin K Yip;Qing Zhong
巨自噬（Macroautophagy，也称为自噬）在维持细胞内稳态中起着关键作用。多步自噬降解途径的终末步骤涉及装载货物的双膜自噬体与溶解性细胞器溶酶体/空泡之间的融合。在过去的十年中，执行这一关键的终端自噬事件的分子机制的各种核心组件已被确定。这篇综述强调了最近的进展，了解分子结构，生化功能，这一高度复杂的机器，包括陷阱融合因子，拴系因子，Rab GTPases和相关的鸟嘌呤核苷酸交换因子，和其他辅助因子的关键组成部分的调控机制。
Macroautophagy (also known as autophagy) plays a pivotal role in maintaining cellular homeostasis. The terminal step of the multi-step autophagy degradation pathway involves fusion between the cargo-laden, double-membraned autophagosome and the lytic organelle lysosome/vacuole. Over the past decade, various core components of the molecular machinery that execute this critical terminal autophagy event have been identified. This review highlights recent advances in understanding the molecular structures, biochemical functions, and regulatory mechanisms of key components of this highly sophisticated machinery including the SNARE fusogens, tethering factors, Rab GTPases and associated guanine nucleotide exchange factors, and other accessory factors.