Green Tea Supplementation Affects Body Weight, Lipids, and Lipid Peroxidation in Obese Subjects with Metabolic Syndrome
Green Tea Supplementation Affects Body Weight, Lipids, and Lipid Peroxidation in Obese Subjects with Metabolic Syndrome
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DOI：
10.1080/07315724.2010.10719814
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发表时间：
2010-02-01
影响因子：
3.5
通讯作者：
Lyons, Timothy J.
中科院分区：
文献类型：
--
作者：
Basu, Arpita;Sanchez, Karah;Lyons, Timothy J.
目的：比较补充绿茶饮料或绿茶提取物与对照组对患有代谢综合征的肥胖受试者的体重、血糖和血脂、氧化应激生物标志物以及安全参数的影响。设计：随机、对照前瞻性试验。地点：俄克拉荷马大学健康科学中心 (OUHSC) 的普通临床研究中心 (GCRC)。受试者：以年龄和性别匹配的三人组招募 35 名患有肥胖和代谢综合征的受试者，并随机分配到对照组（4 杯水/天）、绿茶（4 杯/天）或绿茶提取物（2 粒胶囊和 4 杯水/天）组，持续 8 周。茶组和提取物组的表没食子儿茶素-3-没食子酸酯 (EGCG)（绿茶中的活性化合物）的剂量相似。方法：人体测量、血压、空腹血糖和血脂、基于核磁共振 (NMR) 的脂质粒径、安全参数、氧化应激生物标志物（氧化低密度脂蛋白 [LDL]、髓过氧化物酶 [MPO]、丙二醛和羟基壬烯醛 [MDA 和 HNE]）以及游离脂肪酸在筛选以及研究的第 4 周和第 8 周对儿茶素进行了分析。结果：配对比较显示，与对照组相比，绿茶饮料和绿茶提取物在第 8 周时导致体重和体重指数 (BMI) 显着下降（分别为 -2.5 +/- 0.7 kg，p < 0.01 和 -1.9 +/- 0.6，p < 0.05）。与对照组相比，绿茶饮料的 LDL 胆固醇和 LDL/高密度脂蛋白 (HDL) 呈下降趋势 (p < 0.1)。与对照组相比，绿茶饮料还显着降低了 MDA 和 HNE（-0.39 +/- 0.06 muM，p < 0.0001）。在筛选时和第 8 周时，与对照组相比，饮料组和提取物组中均检测到血浆游离儿茶素，表明绿茶儿茶素的依从性和生物利用度。结论：绿茶饮料消耗（4 杯/天）或提取物补充剂（2 粒/天）持续 8 周显着降低了体重和 BMI。与年龄和性别匹配的对照组相比，绿茶饮料进一步降低了脂质过氧化，表明绿茶黄酮类化合物在改善肥胖患者代谢综合征特征方面的作用。
Objective: To compare the effects of supplementation of green tea beverage or green tea extracts with controls on body weight, glucose and lipid profile, biomarkers of oxidative stress, and safety parameters in obese subjects with metabolic syndrome.Design: Randomized, controlled prospective trial.Setting: General Clinical Research Center (GCRC) at University of Oklahoma Health Sciences Center (OUHSC).Subjects: Thirty-five subjects with obesity and metabolic syndrome were recruited in age- and gender-matched trios and were randomly assigned to the control (4 cups water/d), green tea (4 cups/d), or green tea extract (2 capsules and 4 cups water/d) group for 8 weeks. The tea and extract groups had similar dosing of epiogallocatechin-3-gallate (EGCG), the active compound in green tea.Methods: Anthropometrics, blood pressure, fasting glucose and lipids, nuclear magnetic resonance (NMR) based lipid particle size, safety parameters, biomarkers of oxidative stress (oxidized low-density lipoprotein [LDL], myeloperoxidase [MPO], malondialdehyde and hydroxynonenals [MDA and HNE]), and free catechins were analyzed at screen and at 4 and 8 weeks of the study.Results: Pairwise comparisons showed green tea beverage and green tea extracts caused a significant decrease in body weight and body mass index (BMI) versus controls at 8 weeks (-2.5 +/- 0.7 kg, p < 0.01, and -1.9 +/- 0.6, p < 0.05, respectively). Green tea beverage showed a decreasing trend in LDL-cholesterol and LDL/high-density lipoprotein (HDL) versus controls (p < 0.1). Green tea beverage also significantly decreased MDA and HNE (-0.39 +/- 0.06 mu M, p < 0.0001) versus controls. Plasma free catechins were detectable in both beverage and extract groups versus controls at screen and at 8 weeks, indicating compliance and bioavailability of green tea catechins.Conclusions: Green tea beverage consumption (4 cups/d) or extract supplementation (2 capsules/d) for 8 weeks significantly decreased body weight and BMI. Green tea beverage further lowered lipid peroxidation versus age- and gender-matched controls, suggesting the role of green tea flavonoids in improving features of metabolic syndrome in obese patients.