Copper-Doped Ordered Mesoporous Bioactive Glass: A Promising Multifunctional Platform for Bone Tissue Engineering†
Copper-Doped Ordered Mesoporous Bioactive Glass: A Promising Multifunctional Platform for Bone Tissue Engineering†
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DOI：
10.3390/bioengineering7020045
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发表时间：
2020-06-01
影响因子：
4.6
通讯作者：
Baino, Francesco
中科院分区：
文献类型：
--
作者：
Baino, Francesco
具有多功能特性的生物材料的设计和开发在骨组织工程的背景下是非常有吸引力的，因为它具有提供多种疗法的潜力，从而更好地治疗疾病。为了解决这一难题，采用溶胶-凝胶法和蒸发诱导自组装法，以非离子嵌段共聚物为结构导向剂，合成了铜掺杂硅酸盐介孔生物活性玻璃（MBG）.通过X射线粉末衍射、扫描透射电镜和氮气吸附-脱附等测试手段对煅烧后材料的结构和织构进行了研究。体外生物活性通过在模拟体液（SBF）中的浸泡试验进行评估。还用金黄色葡萄球菌进行了初步的抗菌试验。铜掺杂玻璃显示出有序排列的介孔（直径约5 nm），并表现出磷灰石形成能力，在SBF沿着与有前途的抗菌性能。这些结果表明，铜掺杂的MBG粉末用作多功能生物材料的潜在适用性，以促进骨再生（生物活性）并预防/对抗植入部位的微生物感染，从而促进组织愈合。
The design and development of biomaterials with multifunctional properties is highly attractive in the context of bone tissue engineering due to the potential of providing multiple therapies and, thus, better treatment of diseases. In order to tackle this challenge, copper-doped silicate mesoporous bioactive glasses (MBGs) were synthesized via a sol-gel route coupled with an evaporation-induced self-assembly process by using a non-ionic block co-polymer as a structure directing agent. The structure and textural properties of calcined materials were investigated by X-ray powder diffraction, scanning-transmission electron microscopy and nitrogen adsorption-desorption measurements. In vitro bioactivity was assessed by immersion tests in simulated body fluid (SBF). Preliminary antibacterial tests usingStaphylococcus aureuswere also carried out. Copper-doped glasses revealed an ordered arrangement of mesopores (diameter around 5 nm) and exhibited apatite-forming ability in SBF along with promising antibacterial properties. These results suggest the potential suitability of copper-doped MBG powder for use as a multifunctional biomaterial to promote bone regeneration (bioactivity) and prevent/combat microbial infection at the implantation site, thereby promoting tissue healing.