Distribution of NMDA receptor subunit proteins NR2A, 2B, 2C and 2D in rat brain
Distribution of NMDA receptor subunit proteins NR2A, 2B, 2C and 2D in rat brain
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DOI：
10.1097/00001756-199512000-00010
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发表时间：
1995-12
期刊：
影响因子：
1.7
通讯作者：
A. Wenzel;L. Scheurer;R. Künzi;J. Fritschy;H. Mohler;D. Benke
中科院分区：
文献类型：
--
作者：
A. Wenzel;L. Scheurer;R. Künzi;J. Fritschy;H. Mohler;D. Benke
采用新研制的亚基特异性抗血清组织印迹技术，观察了NMDA受体NR2A、2B、2C和2D在成年大鼠脑中的区域分布。NR2A几乎在大脑的所有区域都有免疫反应，而NR2B仅限于前脑，NR2D对间脑、中脑和脑干结构有免疫反应。NR2C染色仅限于小脑、丘脑和嗅球。因此，含有NR2A亚基的NMDA受体可能代表了一种在整个大脑中占主导地位的受体亚型，而含有NR2B、NR2C或NR2D亚基的NMDA受体则代表了更多的区域特异性受体亚型。某些NR2亚基的区域重叠分布表明存在含有多个NR2亚基变体的NMDA受体。
The regional distribution of the NMDA receptor subunits NR2A, 2B, 2C and 2D was visualized in adult rat brain using the histo-blot technique with newly developed subunit-specific antisera. NR2A immunoreactivity was found in almost all regions of the brain, whereas NR2B staining was restricted to forebrain, and NR2D immunoreactivity to diencephalic, mesencephalic and brain stem structures. NR2C staining was confined to cerebellum, thalamus and olfactory bulb. Thus, NMDA receptors containing the NR2A subunit are likely to represent a receptor subtype predominant throughout the brain, while those containing the NR2B, NR2C or NR2D subunit represent more region-specific receptor subtypes. The regionally overlapping distribution of certain NR2 subunits points to the existence of NMDA receptors containing more than one NR2 subunit variant.