Cryptolepine, Isolated from Sida acuta, Sensitizes Human Gastric Adenocarcinoma Cells to TRAIL-induced Apoptosis
Cryptolepine, Isolated from Sida acuta, Sensitizes Human Gastric Adenocarcinoma Cells to TRAIL-induced Apoptosis
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DOI：
10.1002/ptr.3219
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发表时间：
2011-01-01
影响因子：
7.2
通讯作者：
Ishibashi, Masami
中科院分区：
文献类型：
--
作者：
Ahmed, Firoj;Toume, Kazufumi;Ishibashi, Masami
在生物测定法的指导下，对刺田全株进行分离，分离出一种生物碱，隐tolepine(1)和两种山奈酚苷（2-3）。在1.25、2.5和5 μ m浓度下，化合物1在人胃腺癌（AGS）细胞中表现出较强的抗TRAIL抗性活性，化合物1和TRAIL联合处理可使AGS细胞在上述浓度下对TRAIL诱导的凋亡增敏。版权所有John Wiley & Sons， Ltd。
Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2-3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 mu M. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations. Copyright (C) 2010 John Wiley & Sons, Ltd.