ORAL PROGESTATIONAL ACTIVITY OF SPIRONOLACTONE1

ORAL PROGESTATIONAL ACTIVITY OF SPIRONOLACTONE1
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螺内酯1的口服促孕活性

DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
G. O. Potts
G. O. Potts
中科院分区：
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文献类型：
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作者：
H. P. Schane;G. O. Potts

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螺内酯在家兔和恒河猴中具有促孕活性。在50至200毫克/千克的剂量范围内，它在雌激素致敏的未成熟雌性家兔的子宫内膜中产生腺体发育，在400毫克/只猴子的剂量范围内，它在卵巢切除的猴子中延迟雌激素戒断性出血，并在定期骑自行车的猴子中抑制月经。这些数据与螺内酯治疗期间观察到的女性月经不规律和闭经一致。
Spironolactone has progestational activity in the rabbit and rhesus monkey. It produced glandular development in the endometrium of the estrogen-primed immature female rabbit over the dosage range of 50 to 200 mg/kg and, at 400 mg/monkey, it delayed estrogen-withdrawal bleeding in ovariectomized monkeys and it inhibited menstruation in regularly cycling monkeys. These data are consistent with the menstrual irregularity and amenorrhea seen in women during treatment with spironolactone.