The effects of acrolein on the thioredoxin system: implications for redox-sensitive signaling.
The effects of acrolein on the thioredoxin system: implications for redox-sensitive signaling.
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DOI：
10.1002/mnfr.201100224
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发表时间：
2011-09
影响因子：
5.2
通讯作者：
Szadkowski, Adam
中科院分区：
文献类型：
--
作者：
Myers, Charles R.;Myers, Judith M.;Kufahl, Timothy D.;Forbes, Rachel;Szadkowski, Adam
活性醛丙烯醛是一种普遍存在的环境污染物，也是一种内源性污染物。它是一种强亲电试剂，与包括硫酸盐在内的亲核试剂反应迅速。本文综述了丙烯醛对细胞内蛋白质硫醇氧化还原平衡的主要调节因子硫氧还蛋白还原酶（TrxR）和硫氧还蛋白（Trx）的影响。丙烯醛对TrxR和Trx产生不可逆作用，这与硒代半胱氨酸和半胱氨酸残基形成共价加合物是一致的，这是其活性的关键。TrxR和Trx比其他一些氧化还原敏感蛋白更敏感，它们的长期抑制可能会破坏细胞中的许多氧化还原敏感功能。这些作用包括过氧化物还毒素的氧化和凋亡信号调节激酶（ASK1）的激活。ASK1促进MAP激酶激活，p38激活有助于细胞凋亡和其他一些丙烯醛诱导的应激反应。总的来说，丙烯醛对TrxR/Trx系统的破坏可能是早期和长期的重大事件，影响氧化还原敏感信号和氧化应激的许多方面。
The reactive aldehyde acrolein is a ubiquitous environmental pollutant and is also generated endogenously. It is a strong electrophile and reacts rapidly with nucleophiles including thiolates. This review focuses on the effects of acrolein on thioredoxin reductase (TrxR) and thioredoxin (Trx), which are major regulators of intracellular protein thiol redox balance. Acrolein causes irreversible effects on TrxR and Trx, which are consistent with the formation of covalent adducts to selenocysteine and cysteine residues that are key to their activity. TrxR and Trx are more sensitive than some other redox-sensitive proteins, and their prolonged inhibition could disrupt a number of redox-sensitive functions in cells. Among these effects are the oxidation of peroxiredoxins and the activation of apoptosis signal regulating kinase (ASK1). ASK1 promotes MAP kinase activation, and p38 activation contributes to apoptosis and a number of other acrolein-induced stress responses. Overall, the disruption of the TrxR/Trx system by acrolein could be significant early and prolonged events that affects many aspects of redox-sensitive signaling and oxidant stress.
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影响因子：
3.7
作者：
Anestål K;Prast-Nielsen S;Cenas N;Arnér ES
通讯作者：
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影响因子：
4.1
作者：
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DOI：
10.1152/ajplung.1998.274.4.l591
发表时间：
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影响因子：
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作者：
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作者：
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影响因子：
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作者：
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通讯作者：
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