Reducing parenteral requirement in children with short bowel syndrome: Impact of an amino acid-based complete infant formula
Reducing parenteral requirement in children with short bowel syndrome: Impact of an amino acid-based complete infant formula
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DOI：
10.1097/00005176-199802000-00001
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发表时间：
1998-02-01
影响因子：
2.9
通讯作者：
Hill, D
中科院分区：
文献类型：
--
作者：
Bines, J;Francis, D;Hill, D
背景资料：本研究的目的是评估一种含氨基酸的完全婴儿配方奶粉对严重短肠综合征患儿肠内喂养耐受性和肠外营养需求的影响。四个孩子（23个月-4.75岁），患有短肠综合征，需要长-由于持续喂养不耐受而接受广泛水解配方奶粉的长期肠外营养，开始使用基于氨基酸的完全婴儿配方奶粉，平均随访期为48个月（范围39-51个月）。评估包括临床监测喂养耐受性和营养状况，生化，粪便分析，皮肤点刺试验，共同的食物抗原，食管胃镜检查和结肠镜检查或空肠镜活检，并测量disbrididase水平和肠道permeability.Results：所有患者停止肠外营养数月内，由于粪便产量减少和呕吐的决议。患者的住院时间（平均：198天vs 98天/患者/年）、确诊（平均：4.3天vs 3.3天/患者/年）和疑似（平均：6.5天vs 4.0天/患者/年）细菌性脓毒症和中心静脉导管插入（平均：2.5天vs 1.5天/患者/年）减少。肠对乳果糖的渗透性显著下降（平均值：69% vs 2.7%）。在所有三名患者进行重复study.Conclusions：一个氨基酸为基础的完整的婴儿配方奶粉提高喂养耐受性，消除了肠外营养的需要，在四个孩子短肠综合征谁以前需要长期肠外营养。临床改善反映在肠功能测量的改善上。
Background: The aim of this study was to assess the impact of an amino acid-based complete infant formula on enteral feeding tolerance and parenteral nutrition requirement in children with severe short bowel syndrome.Methods: Four children (23 months-4.75 years) with short bowel syndrome who required long-term parenteral nutrition due to persistent feeding intolerance while receiving an extensively hydrolyzed formula were assessed before and after the commencement of an amino acid-based complete infant formula for a mean follow-up period of 48 months (range 39-51 months). Assessment included clinical monitoring of feeding tolerance and nutritional status, biochemistry, stool analysis, skin-prick testing to common food antigens, esophagogastroduodenoscopy and colonoscopy or jejunoscopy with biopsies, and measurement of disaccharidase levels and intestinal permeability.Results: All patients ceased parenteral nutrition within months as a result of decreased stool output and resolution of vomiting. Patients had a reduction in hospitalization (mean: 198 versus 98 days/patient/year), episodes of proven (mean: 4.3 versus 3.3/patient/year) and suspected (mean: 6.5 versus 4.0/ patient/year) bacterial sepsis and central line insertions (mean: 2.5 versus 1.5/patient/year). Intestinal permeability to lactulose fell markedly (mean: 69% versus 2.7%). Disaccharidase levels increased in all three patients undergoing repeat studies.Conclusions: An amino acid-based complete infant formula improved feeding tolerance and eliminated the need for parenteral nutrition in four children with short bowel syndrome who had previously required long-term parenteral nutrition. The clinical improvement was mirrored by improvement in measurements of intestinal function.