Ratio of urinary N-terminal titin fragment to urinary creatinine is a novel biomarker for amyotrophic lateral sclerosis
Ratio of urinary N-terminal titin fragment to urinary creatinine is a novel biomarker for amyotrophic lateral sclerosis
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DOI：
10.1136/jnnp-2020-324615
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发表时间：
2021-10-01
影响因子：
11
通讯作者：
Katsuno, Masahisa
中科院分区：
文献类型：
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作者：
Yamada, Shinichiro;Hashizume, Atsushi;Katsuno, Masahisa
目的探讨尿n端titin片段作为肌萎缩性侧索硬化症（ALS）生物标志物的有效性。方法连续入组70例ALS患者和43例健康对照。我们评估了尿titin n端片段、尿神经营养因子受体p75细胞外结构域、血清神经丝轻链（NfL）、运动功能测量和预后。我们用尿肌酐（Cr）水平使尿中titin片段的水平正常化。结果与HC相比，ALS患者尿中titin n端片段Cr正常化（titin/Cr）水平显著升高(ALS为27.2 pmol/mg/dL； HC为5.8 pmol/mg/dL
Objective We aimed to investigate the validity of urinary N-terminal titin fragment as a biomarker for amyotrophic lateral sclerosis (ALS).Methods We consecutively enrolled patients with ALS (n=70) and healthy controls (HC) (n=43). We assessed the urinary titin N-terminal fragment, urinary neurotrophin receptor p75 extracellular domain, serum neurofilament light chain (NfL), motor functional measurements and prognosis. We used urinary creatinine (Cr) levels to normalise the urinary levels of titin fragment.Results Compared with HC, patients with ALS had significantly increased urinary levels of titin N-terminal fragment normalised with Cr (titin/Cr) (ALS, 27.2 pmol/mg/dL; HC, 5.8 pmol/mg/dL; p