Development of Upper Respiratory Tract Microbiota in Infancy is Affected by Mode of Delivery.
Development of Upper Respiratory Tract Microbiota in Infancy is Affected by Mode of Delivery.
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DOI：
10.1016/j.ebiom.2016.05.031
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发表时间：
2016-07
期刊：
影响因子：
11.1
通讯作者：
Bogaert D
中科院分区：
文献类型：
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作者：
Bosch AATM;Levin E;van Houten MA;Hasrat R;Kalkman G;Biesbroek G;de Steenhuijsen Piters WAA;de Groot PCM;Pernet P;Keijser BJF;Sanders EAM;Bogaert D
剖腹产与短期和长期呼吸系统疾病有关。我们假设递送模式影响呼吸道微生物群的发育，从而改变其提供定植抗性和连续致病菌过度生长和感染的能力。因此，我们纵向研究了分娩方式对102名健康新生儿（n = 761个样本）从出生到6个月龄的鼻咽微生物群发育的影响。在这里，我们表明，呼吸道微生物群在一天内从可变的混合细菌群落发展到草绿色链球菌占主导地位的概况，无论输送模式如何。在第一周内，发生了快速的生态位分化;最初在大多数婴儿中以金黄色葡萄球菌为主，随后分化为以假白喉棒状杆菌/propinquum、Dolosigranulum pigrum、卡他莫拉菌/非卡他莫拉菌、肺炎链球菌和/或流感嗜血杆菌为主的群落。通过剖腹产出生的婴儿表现出呼吸道微生物群特征的总体发育延迟，特别是减少了健康相关细菌如棒状杆菌和Dolosigranulum的定植，从而可能影响以后的呼吸道健康。呼吸道微生物群在生命的前六个月是高度动态的。微生物群从母体/环境来源的植物群迅速发展到几个生态位特异性概况。递送方式影响早期呼吸道微生物群的发育，特别是潜在保护性肠道的定殖。剖腹产与呼吸系统疾病的发病率增加有关。我们假设，递送方式影响呼吸道中的细菌微群落（微生物群），从而影响其防止可能导致呼吸道疾病的潜在病原菌入侵和生长的能力。我们在儿童出生后的前六个月对他们进行了跟踪，结果表明，微生物群从母体/环境来源的植物群迅速发展到几种特定于生态位的微生物。分娩方式会显著影响呼吸道微生物群的发育，并与母乳喂养相互作用，特别是在早期存在潜在的保护性细菌方面，这可能有助于以后的呼吸道健康。
Birth by Caesarian section is associated with short- and long-term respiratory morbidity. We hypothesized that mode of delivery affects the development of the respiratory microbiota, thereby altering its capacity to provide colonization resistance and consecutive pathobiont overgrowth and infections. Therefore, we longitudinally studied the impact of mode of delivery on the nasopharyngeal microbiota development from birth until six months of age in a healthy, unselected birth cohort of 102 children (n = 761 samples). Here, we show that the respiratory microbiota develops within one day from a variable mixed bacterial community towards a Streptococcus viridans-predominated profile, regardless of mode of delivery. Within the first week, rapid niche differentiation had occurred; initially with in most infants Staphylococcus aureus predominance, followed by differentiation towards Corynebacterium pseudodiphteriticum/propinquum, Dolosigranulum pigrum, Moraxella catarrhalis/nonliquefaciens, Streptococcus pneumoniae, and/or Haemophilus influenzae dominated communities. Infants born by Caesarian section showed a delay in overall development of respiratory microbiota profiles with specifically reduced colonization with health-associated commensals like Corynebacterium and Dolosigranulum, thereby possibly influencing respiratory health later in life. The respiratory microbiota is highly dynamic during the first six months of life. The microbiota develops rapidly from a maternal/environmental-derived flora towards several niche-specific profiles. Mode of delivery affects early respiratory microbiota development, especially colonization of potential protective commensals. Birth by Caesarian section is associated with increased prevalence of respiratory diseases. We hypothesized that mode of delivery affects the micro-community of bacteria residing in the respiratory tract (microbiota), thereby influencing its ability to prevent invasion and outgrowth of potential pathogenic bacteria that can cause respiratory disease. We followed children during their first six months of life and show that the microbiota develops rapidly from a maternal/environmental-derived flora towards several niche-specific microbial profiles. Mode of delivery significantly affects respiratory microbiota development and interacts with breastfeeding, especially regarding the early presence of potential protective bacteria, which may contribute to respiratory health later in life.