[A hairy B cell lymphoproliferative disorder resembling hairy cell leukemia].
[A hairy B cell lymphoproliferative disorder resembling hairy cell leukemia].
复制标题
[一种类似于毛细胞白血病的毛状 B 细胞淋巴增殖性疾病]。
DOI：
10.11406/rinketsu.45.312
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
T. Machii
中科院分区：
文献类型：
--
作者：
Y. Yagi;H. Sakabe;R. Kakinoki;Kou Yoshikawa;Tetsuya Inoue;Y. Fujiyama;T. Machii
This case report describes a hairy B cell lymphoproliferative disorder (HBLD) with clinical and hematological features resembling hairy cell leukemia. The patient was a 29-year-old female who demonstrated atypical lymphocytes in her peripheral blood. Physical examination demonstrated splenomegaly, but there were no palpable superficial lymph nodes. Hematological examination showed a leukocyte count of 10.6 x 10(3)/mm3 with 41% atypical lymphocytes. Bone marrow examination showed a normal cellular and an atypical lymphocyte count of 42%. The atypical lymphocytes had microvilli and prominent membranous ruffles on their surfaces. Atypical lymphocytes expressed CD5- CD10- CD11c+ CD19+ CD20+ CD23- CD25- on the surface of the cells on examination by with a fluorescence activated cell sorter. Although these findings were similar to hairy cell leukemia, Japanese variant, the surface marker of the kappa chain and lambda chain was unbiased and studies of immunoglobulin gene rearrangements and expression showed polyclonal proliferation of B cells. Therefore, we diagnosed this patient as having HBLD. Because she did not demonstrate anemia or thrombocytopenia, she is not currently receiving medication. To date, the atypical lymphocyte count has not changed.
Machii T、Tokumine Y、Inoue R、Kitani T：“日本毛细胞白血病的独特亚型占主导地位”白血病。
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--