A 3 W continuous-wave 589 nm yellow laser based on the intracavity sum frequency generation in a V-shaped cavity
A 3 W continuous-wave 589 nm yellow laser based on the intracavity sum frequency generation in a V-shaped cavity
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DOI：
10.7498/aps.55.5227
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发表时间：
2006-10
影响因子：
1
通讯作者：
Geng Ai-Cong;Bo Yong;Bi Yong;Sun Zhi-Pei;Yang Xiao-dong;Lu Yuan-fu;Chen Ya-hui;Guo Lin;Wang Gui-ling;Cui Da-Fu;Xu Zu-yan
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文献类型：
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作者：
Geng Ai-Cong;Bo Yong;Bi Yong;Sun Zhi-Pei;Yang Xiao-dong;Lu Yuan-fu;Chen Ya-hui;Guo Lin;Wang Gui-ling;Cui Da-Fu;Xu Zu-yan
A model for the unidirectional movement of dynein is presented based on the structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule (MT) is independent of its nucleotide state and the change between strong and weak MT-binding is determined naturally by the variation of relative orientation between the stalk and MT, as the stalk rotates following nucleotide-state transition. Thus the enigmatic communication from the adenosine triphosphate (ATP)-binding site in the globular domain to the far MT-binding site in the tip of the stalk, which is a prerequisite in conventional models, is not required. Using the present model, the previous experimental results such as the effect of ATP and adenosine diphosphate (ADP) bindings on dissociation of dynein from MT, the movement of single-headed axonemal dyneins at saturating ATP concentration, the load dependence of step-size for the movement of two-headed cytoplasmic dyneins and the dependence of stall force on ATP concentration can be well explained.
