Practical chemoenzymatic dynamic kinetic resolution of primary amines via transfer of a readily removable benzyloxycarbonyl group
Practical chemoenzymatic dynamic kinetic resolution of primary amines via transfer of a readily removable benzyloxycarbonyl group
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DOI：
10.1016/j.tetlet.2007.12.017
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发表时间：
2008-02-04
影响因子：
1.8
通讯作者：
Backvall, Jan-E.
中科院分区：
文献类型：
--
作者：
Hoben, Christine E.;Kanupp, Lisa;Backvall, Jan-E.
以碳酸二苄酯为酰基供体，发展了一种实用的伯胺化学酶动力学拆分方法，得到氨基甲酸苄酯，后者可在非常温和的反应条件下脱保护得到游离胺。(c)2007爱思唯尔有限公司保留所有权利。
A practical method for chemoenzymatic dynamic kinetic resolution of primary amines using dibenzyl carbonate as acyl donor has been developed leading to benzyl carbamates, which can be deprotected under very mild reaction conditions to give the free amine. (c) 2007 Elsevier Ltd. All rights reserved.