Eurotium cristatum, a potential probiotic fungus from Fuzhuan brick tea, alleviated obesity in mice by modulating gut microbiota
Eurotium cristatum, a potential probiotic fungus from Fuzhuan brick tea, alleviated obesity in mice by modulating gut microbiota
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DOI：
10.1039/c9fo00604d
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发表时间：
2019-08-01
期刊：
影响因子：
6.1
通讯作者：
Huang, Yong
中科院分区：
文献类型：
--
作者：
Kang, Dingding;Su, Meng;Huang, Yong
肥胖是世界范围内主要的公共卫生问题之一，主要是由不健康的生活方式和饮食造成的。肠道菌群失调可能导致人类和动物肥胖。通过益生菌或某些膳食补充剂调节肠道细菌可以使肠道微生物群正常化，从而减轻肥胖。每日饮用扶正砖茶（FBT）或其提取物已被观察到可以减轻人类和实验动物的肥胖。在本研究中，高脂肪饮食（HFD）诱导的小鼠肥胖，如体重增加和脂肪积累，通过消耗Eurotium cristatum （FBT的制造和储存过程中的优势真菌）来预防。C57BL/6J小鼠肠道菌群失调也部分正常化。根据对小鼠粪便样本（n = 5）微生物群组成的分析，冠状芽孢杆菌能够调节肠道真菌和细菌组成。鸡冠乳杆菌增加小鼠肠道中产生乙酸和丁酸的细菌。喂食冠状乳杆菌的小鼠粪便样品中丁酸盐含量是未喂食冠状乳杆菌的小鼠粪便样品的5倍。我们的研究结果表明，冠状芽孢杆菌可能作为一种益生菌真菌，对减轻人类肥胖和调节肠道微生物群有益。
Obesity is one of the major public health problems worldwide, mainly resulting from unhealthy lifestyles and diet. Gut microbiota dysbiosis may lead to obese humans and animals. Modulating gut bacteria through probiotics or certain dietary supplements could normalize gut microbiota and subsequently alleviate obesity. The daily consumption of Fuzhuan brick tea (FBT) or its extracts has been observed to alleviate obesity in humans and experimental animals. In this study, high-fat diet (HFD)-induced obesity in mice, such as body weight gain and fat accumulation, was prevented by the consumption of Eurotium cristatum, the dominant fungus during the manufacturing and storage of FBT. The dysbiosis of gut microbiota in C57BL/6J mice was also partially normalized. E. cristatum was able to modulate both gut fungal and bacterial compositions, based on the analysis of the microbiota composition of mice fecal samples (n = 5). E. cristatum increased acetate and butyrate-producing bacteria in mouse gut. There was five times more butyrate in the fecal samples from mice fed with E. cristatum than that from untreated HFD mice. Our results suggest that E. cristatum may be used as a probiotic fungus to alleviate obesity and to modulate gut microbiota in humans beneficially.