Vertebrate limb development.
Vertebrate limb development.
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脊椎动物的肢体发育。
DOI：
10.1016/0959-437x(95)90052-i
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发表时间：
1995
影响因子：
4
通讯作者：
Cheryll Tickle
中科院分区：
文献类型：
--
作者：
Cheryll Tickle
最近发现WNT-7a是背侧/腹侧模式中的信号分子，这意味着我们现在有了一个已知的信号来控制三个肢体轴中的每一个。成纤维细胞生长因子可以实现近端/远端的图案化，而Sonic hedgehog基因的表达则是前后部图案化的信号。这些信号的网络不仅协调细胞的反应，而且相互维持。建立了一个正反馈环，协调Sonic hedgehog在极化区间充质细胞中的表达和在覆盖的顶脊外胚层中的FGF-4表达。WNT-7a在背侧外胚层的表达也影响极化区域的Sonic Hedgehog表达。只需一种信号，即生长因子，就可以启动完整肢体的发育。
The recent identification of Wnt-7a as a signalling molecule in dorsal/ventral patterning means that we now have a known signal for control of each of the three limb axes. Fibroblast growth factors can allow proximal/distal patterning and Sonic hedgehog gene expression signals anterior/posterior patterning. Networks of these signals not only coordinate cell responses, but also mutually maintain each other. A positive feedback loop is established which coordinates expression of Sonic hedgehog in mesenchyme cells of the polarizing region and Fgf-4 expression in overlying apical ridge ectoderm. Wnt-7a expression in dorsal ectoderm also influences Sonic hedgehog expression in the polarizing region. Initiation of development of a complete limb can be achieved with just one signal, a growth factor.