Erratum to: Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes.
Erratum to: Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes.
复制标题
勘误表：白蛋白尿和肾小球滤过率对日本 2 型糖尿病患者的肾脏和心血管事件以及全因死亡率的临床影响。
DOI：
10.1007/s10157-013-0931-4
复制
发表时间：
2014
期刊：
影响因子：
2.3
通讯作者：
Ministry of Health,
中科院分区：
文献类型：
--
作者：
Wada T;Haneda M;Furuichi K;Babazono T;Yokoyama H;Iseki K;Araki SI;Ninomiya T;Hara S;Suzuki Y;Iwano M;Kusano E;Moriya T;Satoh H;Nakamura H;Shimizu M;Toyama T;Hara A;Makino H;The Research Group of Diabetic Nephropathy;Ministry of Health,
背景世界范围内，糖尿病肾病导致终末期肾病的患者数量正在增加。在临床环境中，关于尿白蛋白/肌酐比(UACR)和估计肾小球滤过率(EGFR)降低对肾脏和心血管结局以及全因死亡率的影响的数据有限。方法我们对来自10个中心的4328名日本2型糖尿病参与者进行了历史队列研究。根据UACR和EGFR水平评估肾脏事件(需要透析或移植，或EGFR减半)、心血管事件(心血管死亡、非致命性心肌梗死或非致命性中风)和全因死亡的风险。结果在随访期间(中位数7.0年，四分位数范围3.0-8.0年)，发生419例肾脏事件，605例心血管事件和236例死亡。UACR水平增加了这三个事件的风险和调整后的危险比。除了UACR水平的影响外，EGFR分期还显著增加了调整后的肾脏事件风险比和全因死亡率，尤其是在大量蛋白尿患者中。结论UACR水平升高与日本2型糖尿病患者肾脏、心血管事件和全因死亡率的增加密切相关，而UACR水平升高和EGFR降低是肾脏事件的强烈预测因子。
BackgroundThe number of patients suffering from diabetic nephropathy resulting in end-stage kidney disease is increasing worldwide. In clinical settings, there are limited data regarding the impact of the urinary albumin-to-creatinine ratio (UACR) and reduced estimated glomerular filtration rate (eGFR) on renal and cardiovascular outcomes and all-cause mortality.MethodsWe performed a historical cohort study of 4328 Japanese participants with type 2 diabetes from 10 centers. Risks for renal events (requirement for dialysis or transplantation, or half reduction in eGFR), cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke), and all-cause mortality were assessed according to UACR and eGFR levels.ResultsDuring follow-up (median 7.0 years, interquartile range 3.0–8.0 years), 419 renal events, 605 cardiovascular events and 236 deaths occurred. The UACR levels increased the risk and the adjusted hazard ratios for these three events. In addition to the effects of UACR levels, eGFR stages significantly increased the adjusted hazard ratios for renal events and all-cause mortality, especially in patients with macroalbuminuria. Diabetic nephropathy score, based on the prognostic factors, well predicted incidence rates per 1000 patient/year for each event.ConclusionsIncreased UACR levels were closely related to the increase in risks for renal, cardiovascular events and all-cause mortality in Japanese patients with type 2 diabetes, whereas the association between high levels of UACR and reduced eGFR was a strong predictor for renal events.