The role of enhancer RNAs in epigenetic regulation of gene expression.

The role of enhancer RNAs in epigenetic regulation of gene expression.
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增强子 RNA 在基因表达的表观遗传调控中的作用。

DOI:
10.1080/21541264.2019.1698934
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发表时间:
2020
期刊:
Transcription
影响因子:
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通讯作者:
Lauberth,ShannonM
Lauberth,ShannonM
中科院分区:
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文献类型:
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作者:
Rahnamoun,Homa;Orozco,Paola;Lauberth,ShannonM

文献摘要

相似文献

自从发现增强子可以支持转录以来,增强子RNA的作用在很大程度上仍然难以捉摸。我们发现增强子RNA与溴域相互作用,并增强与乙酰化染色质的接触。在这里,我们讨论我们的最新发现和潜在的潜在机制的调节和功能的增强子RNA-溴域联合。
Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.