The role of enhancer RNAs in epigenetic regulation of gene expression.
The role of enhancer RNAs in epigenetic regulation of gene expression.
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增强子 RNA 在基因表达的表观遗传调控中的作用。
DOI:
10.1080/21541264.2019.1698934
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发表时间:
2020
期刊:
影响因子:
--
通讯作者:
Lauberth,ShannonM
中科院分区:
文献类型:
--
作者:
Rahnamoun,Homa;Orozco,Paola;Lauberth,ShannonM
Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.