F-Actin Cytoskeleton Network Self-Organization Through Competition and Cooperation.
F-Actin Cytoskeleton Network Self-Organization Through Competition and Cooperation.
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DOI:
10.1146/annurev-cellbio-032320-094706
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发表时间:
2020-10-06
影响因子:
11.3
通讯作者:
Kovar DR
中科院分区:
文献类型:
--
作者:
Kadzik RS;Homa KE;Kovar DR
Many fundamental cellular processes such as division, polarization, endocytosis, and motility require the assembly, maintenance and disassembly of actin filament (F-actin) networks at specific locations and times within the cell. The particular function of each network is governed by F-actin organization, size and density, as well as actin filament dynamics. The distinct characteristics of different F-actin networks are determined through the coordinated action of specific sets of actin binding proteins (ABPs). Furthermore, cells typically assemble and use multiple F-actin networks simultaneously within the same cytoplasm, so networks must self-organize from a common pool of shared actin monomers (G-actin) and overlapping sets of ABPs. Recent advances in multi-color imaging and analysis of ABPs and their associated F-actin networks in cells, as well as the development of sophisticated in vitro reconstitutions of networks with ensembles of ABPs, has allowed the field to start uncovering the underlying principles by which cells self-organize diverse F-actin networks to execute basic cellular functions.
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DOI:
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发表时间:
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发表时间:
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期刊:
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