Synthesis of Saponins using partially protected glycosyl donors
Synthesis of Saponins using partially protected glycosyl donors
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DOI：
10.1021/ol035353s
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发表时间：
2003-10-02
期刊：
影响因子：
5.2
通讯作者：
Linhardt, RJ
中科院分区：
文献类型：
--
作者：
Du, YG;Gu, GF;Linhardt, RJ
在标准糖基化条件下研究了一类新的具有未保护的2-和2，4-羟基的糖基供体。这种方法被证明是一般有效的烷基和甾体糖苷的合成。利用这些部分保护的供体，在四个简单的顺序反应中以35%的总收率制备了含有2，4-支链寡糖的天然皂苷。
A new class of glycosyl donors having unprotected 2- and 2,4-hydroxyl groups were investigated under the standard glycosylation conditions. This approach was shown to be generally effective for the synthesis of alkyl and steroidal glycosides. A natural saponin, containing 2,4-branched oligosaccharide, was prepared in 35% overall yield in four straightforward sequential reactions by taking advantage of these partially protected donors.