The influence of living donor SHROOM3 and ABCB1 genetic variants on renal function after kidney transplantation
The influence of living donor SHROOM3 and ABCB1 genetic variants on renal function after kidney transplantation
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活体供体SHROOM3和ABCB1基因变异对肾移植后肾功能的影响
DOI：
10.1097/fpc.0000000000000251
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Wang L. L.
中科院分区：
文献类型：
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作者：
Yan L.;Li Y.;Tang J. T.;An Y. F.;Luo L. M.;Dai B.;Shi Y. Y.;Wang L. L.
目的一项全基因组关联研究发现了几种与肾功能丧失相关的基因多态性。这些变异对接受免疫抑制治疗的肾移植受者肾功能的影响尚不清楚。材料与方法从四川大学华西医院招募189名肾移植受者及其活体供者，评估5个单核苷酸多态性与肾移植后肾功能的关系。结果SHROOM3 （SHROOM3家族成员）rs17319721位点A等位基因移植后1 ~ 6月，血清肌酐测定的肾小球滤过率显著高于GG基因型移植组（P= 0.020）。协变量调整分析显示，SHROOM3中rs17319721位点的变异是移植后1个月肾功能不全的独立危险因素（P= 0.022）。同时携带SHROOM3中rs17319721等位基因A和ABCB1中rs1045642等位基因CC的受体的肾小球滤过率最低（P< 0.05）。结论供者SHROOM3和ABCB1基因变异与肾移植术后肾功能密切相关。
ObjectiveA genome-wide association study has identified several gene polymorphisms associated with loss of renal function. The effect of these variants on renal function in kidney transplant recipients receiving immunosuppressive treatment is unknown.Materials and methodsA cohort of 189 kidney transplant recipients and their living donors were recruited from West China Hospital of Sichuan University, on whom we assessed the association of five single nucleotide polymorphisms with renal function after kidney transplantation.ResultsGlomerular filtration rate estimated by serum creatinine was significantly higher in recipients carrying allograft with the A allele at rs17319721 in SHROOM3 (shroom family member 3) than those in the group with the GG genotype from month 1 to month 6 after transplantation (P= 0.020). Covariate adjustment analysis showed that the variant at rs17319721 in SHROOM3 was an independent risk factor for renal dysfunction after the first month after transplantation (P= 0.022). The estimated glomerular filtration rate was the lowest in recipients with allograft carrying both the A allele at rs17319721 in SHROOM3 and the CC genotype at rs1045642 in ABCB1 (P< 0.05).ConclusionThe genetic variants in SHROOM3 and ABCB1 in donors were associated closely with renal function after kidney transplantation.