Effects of the electrical double layer and dispersive tissue properties in a volume conduction model of deep brain stimulation
Effects of the electrical double layer and dispersive tissue properties in a volume conduction model of deep brain stimulation
复制标题
深部脑刺激体积传导模型中双电层和色散组织特性的影响
DOI：
--
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
M. Lowery
中科院分区：
文献类型：
--
作者：
P. F. Grant;M. Lowery
本研究的目的是探讨电极-组织界面和色散组织特性对深部脑刺激波形的相互作用。建立了具有分布阻抗的双电层有限元模型。在恒流刺激下，组织电容和色散改变了电压波形。当电极被导电盐水或白质组织包围时，在电压控制刺激下，双电层占主导地位。然而，随着封装组织电阻率的增加，为了模拟慢性刺激，电压波形接近恒流刺激期间观察到的电压波形，频率相关材料特性的影响再次成为主导。
The aim of this study was to investigate the interaction of the electrode-tissue interface and dispersive tissue properties on waveforms used for deep brain stimulation. A finite element model with a distributed impedance electrical double layer was developed. Bulk tissue capacitance and dispersion were found to alter the voltage waveform under constant current stimulation. When the electrode was surrounded by conductive saline or white matter tissue, the electrical double layer was dominant under voltage controlled stimulation. However, as encapsulation tissue resistivity was increased, to emulate chronic stimulation, the voltage waveform approached that observed during constant current stimulation and the influence of the frequency dependent material properties again became dominant.