Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium
Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium
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DOI：
10.1111/jgs.16372
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发表时间：
2020-07-01
影响因子：
6.3
通讯作者：
Cawthon, Peggy M.
中科院分区：
文献类型：
--
作者：
Bhasin, Shalender;Travison, Thomas G.;Cawthon, Peggy M.
制定一个以证据为基础的肌肉减少症定义，以便于识别具有临床相关结局风险的老年人（例如，自我报告的活动受限、福尔斯、骨折和死亡率），肌肉减少症定义和结局联盟（SDOC）通过文献综述和SDOC对8项流行病学研究、6项随机临床试验、四项特殊人群队列研究和两项全国代表性人群研究。方法：由一个独立的国际专家小组（专家组）反复审查了13个与少肌症定义的假定组成部分相关的立场声明，并在少肌症立场声明会议期间由专家组投票。四个位置的陈述有关的握力，三个瘦体重来自双能X线吸收测定法（DXA），和四个步态速度;两个是总结性陈述。结果SDOC分析确定握力，无论是绝对的或缩放到身体大小的措施，作为一个重要的缓慢性。在社区居住的老年人中，低握力和低通常步态速度独立预测福尔斯、自我报告的活动受限、髋部骨折和死亡率。DXA测量的瘦体重与社区居住的老年人的不良健康相关结果无关，无论是否调整体型。结论专家组一致认为，由低握力定义的虚弱和由低通常步态速度定义的缓慢都应包括在肌肉减少症的定义中。这些立场声明为肌肉减少症的循证定义提供了合理的基础。本文总结了这些立场声明的分析，并在本期杂志的随附文章中进行了讨论。J Am Geriatr Soc 68：1410-1418，2020.
OBJECTIVES To develop an evidence-based definition of sarcopenia that can facilitate identification of older adults at risk for clinically relevant outcomes (eg, self-reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition and Outcomes Consortium (SDOC) crafted a set of position statements informed by a literature review and SDOC's analyses of eight epidemiologic studies, six randomized clinical trials, four cohort studies of special populations, and two nationally representative population-based studies. METHODS Thirteen position statements related to the putative components of a sarcopenia definition, informed by the SDOC analyses and literature synthesis, were reviewed by an independent international expert panel (panel) iteratively and voted on by the panel during the Sarcopenia Position Statement Conference. Four position statements related to grip strength, three to lean mass derived from dual-energy x-ray absorptiometry (DXA), and four to gait speed; two were summary statements. RESULTS The SDOC analyses identified grip strength, either absolute or scaled to measures of body size, as an important discriminator of slowness. Both low grip strength and low usual gait speed independently predicted falls, self-reported mobility limitation, hip fractures, and mortality in community-dwelling older adults. Lean mass measured by DXA was not associated with incident adverse health-related outcomes in community-dwelling older adults with or without adjustment for body size. CONCLUSION The panel agreed that both weakness defined by low grip strength and slowness defined by low usual gait speed should be included in the definition of sarcopenia. These position statements offer a rational basis for an evidence-based definition of sarcopenia. The analyses that informed these position statements are summarized in this article and discussed in accompanying articles in this issue of the journal. J Am Geriatr Soc 68:1410-1418, 2020.