Type III export: new uses for an old pathway.
Type III export: new uses for an old pathway.
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III 类出口：旧途径的新用途。
DOI：
10.1046/j.1365-2958.2001.02354.x
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发表时间：
2001
影响因子：
3.6
通讯作者：
Ferracci,F
中科院分区：
文献类型：
--
作者：
Plano,GV;Day,JB;Ferracci,F
革兰氏阴性细菌利用III型分泌（TTS）系统将蛋白质转运到细胞外环境或直接进入真核细胞。这些复杂的分泌系统由20多种不同的结构蛋白组成，其中10种在鞭毛输出途径中有对应的结构蛋白。分泌底物通过mRNA和/或氨基酸分泌信号被定向到TTS机制。TTS伴侣结合选择分泌底物并协助输出过程。综述了近年来对TTS的认识进展。
Gram‐negative bacteria use type III secretion (TTS) systems to translocate proteins into the extracellular environment or directly into eukaryotic cells. These complex secretory systems are assembled from over 20 different structural proteins, including 10 that have counterparts in the flagellar export pathway. Secretion substrates are directed to the TTS machinery via mRNA and/or amino acid secretion signals. TTS chaperones bind to select secretion substrates and assist in the export process. Recent progress in the understanding of TTS is reviewed.