Permanent His-bundle pacing for cardiac resynchronization therapy: Initial feasibility study in lieu of left ventricular lead
Permanent His-bundle pacing for cardiac resynchronization therapy: Initial feasibility study in lieu of left ventricular lead
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DOI：
10.1016/j.hrthm.2017.04.003
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发表时间：
2017-09-01
期刊：
影响因子：
5.5
通讯作者：
Tung, Roderick
中科院分区：
文献类型：
--
作者：
Ajijola, Olujimi A.;Upadhyay, Gaurav A.;Tung, Roderick
背景永久希氏束起搏（HBP）有可能使束分支传导阻滞和心肌病患者的宽QRS时限生理正常化。目的本研究的目的是评估将希氏束电极导线用于心脏起搏治疗（CRT）代替冠状窦电极导线的可行性。尝试将HBP植入左心室（LV）电极导线端口。心内间隔，QRS波持续时间，纽约心脏协会功能分级，射血分数（EF），超声心动图，并在后续follow-up. Results的21例患者中，HBP被成功植入16（年龄62 +/- 18岁，4名女性，EF 25 +/- 8）。观察到平均QRS显著降低，从180 +/- 23 ms缩窄至129 +/- 13 ms（P
BACKGROUND Permanent His-bundle pacing (HBP) has the potential to physiologically normalize wide QRS duration in patients with bundle branch block and cardiomyopathy.OBJECTIVE The purpose of this study was to assess the feasibility of incorporating a His-bundle lead for cardiac resynchronization therapy (CRT) in lieu of a coronary sinus lead.METHODS Patients with an indication for CRT (n = 21) underwent attempted implantation of an HBP placed into the left ventricular (LV) lead port. Intracardiac intervals, QRS duration, New York Heart Association functional class, ejection fraction (EF), echocardiography, and lead characteristics were measured at baseline and at follow-up.RESULTS Of the 21 patients in whom implantation was attempted, HBP was successfully implanted in 16 (age 62 +/- 18 years, 4 females, EF 25 +/- 8). A significant reduction in mean QRS was observed, with narrowing from 180 +/- 23 ms to 129 +/- 13 ms (P