Gestational weight gain and adiposity, fat distribution, metabolic profile, and blood pressure in offspring: the IDEFICS project
Gestational weight gain and adiposity, fat distribution, metabolic profile, and blood pressure in offspring: the IDEFICS project
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DOI：
10.1038/ijo.2013.35
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发表时间：
2013-07-01
影响因子：
4.9
通讯作者：
Siani, A.
中科院分区：
文献类型：
--
作者：
Dello Russo, M.;Ahrens, W.;Siani, A.
目的：为了探讨妊娠期体重增加（GWG）和总肥胖，体脂分布，血压（BP），代谢profile.DESIGN：横断面study.METHODS：体重指数（BMI），腰围，肩胛下和躯干皮褶厚度，和BP之间的关联进行了测量和血液样本抽取12775名儿童（年龄2-9岁）从IDEFICS队列。根据IOTF标准定义超重/肥胖。父母填写了一份调查儿童和熟悉的病史和生活方式的问卷。有一节专门介绍怀孕史结果：人体测量指标在GWG三分位数间呈线性显著增加（BMI z评分：三分位I = 0.08，0.03-0.13;三分位II = 0.16，0.12-0.21;三分位数III = 0.34，0.28-0.40，P < 0.01，平均值，95% CI），通过协方差分析（ANCOVA）进行校正，校正因素包括儿童性别、年龄和运动实践、出生体重、当前母亲BMI、父母教育、孕龄、分娩年龄、妊娠期间饮酒和吸烟，母亲糖尿病、妊娠期高血压和母乳喂养持续时间。将BMI z评分纳入协变量后，HbA 1c在三分位数间显著升高（P = 0.009），而BP、血清胰岛素、HOMA指数、血糖和血脂无差异。调整后的超重/肥胖的风险显着增加了14和22%，分别在三分位数II和III，在与三分位数I相比，通过logistic回归分析控制协变量.CONCLUSION：母亲GWG是一个独立的预测总肥胖和体脂分布在后代在婴儿期。早期预防超重和肥胖应考虑围产期因素。
OBJECTIVE: To investigate the association between gestational weight gain (GWG) and total adiposity, body fat distribution, blood pressure (BP), and metabolic profile in offspring.DESIGN: Cross-sectional study.METHODS: Body mass index (BMI), waist, subscapular and tricipital skinfolds, and BP were measured and blood samples drawn in 12 775 children (aged 2-9 years) from the IDEFICS cohort. Overweight/obesity was defined by IOTF criteria. Parents filled in a questionnaire investigating child and familiar medical history and lifestyle. A section was dedicated to pregnancy history (including GWG).RESULTS: Anthropometric indices linearly and significantly increased across GWG tertiles (BMI z-score: tertile I = 0.08, 0.03-0.13; tertile II = 0.16, 0.12-0.21; tertile III = 0.34, 0.28-0.40, P < 0.01, mean, 95% CI) by analysis of covariance (ANCOVA) adjusted by child sex, age and practice of sport, birth weight, current maternal BMI, parental education, gestational age, age at delivery, alcohol and smoking during pregnancy, maternal diabetes mellitus, gestational hypertension, and breastfeeding duration. After inclusion of BMI z-score among covariates, HbA1c significantly increased across tertiles (P = 0.009) while no differences were observed for BP, serum insulin, HOMA index, blood glucose and lipids. The adjusted risk of overweight/obesity significantly increased by 14 and 22% in tertiles II and III respectively, in comparison with tertile I by logistic regression analysis controlling for covariates.CONCLUSION: Maternal GWG is an independent predictor of total adiposity and body fat distribution in offspring during infancy. Exposure to perinatal factors should be taken into account for early prevention of overweight and obesity.