Synthesis of benzophenone-containing analogues of phosphatidylcholine.
Synthesis of benzophenone-containing analogues of phosphatidylcholine.
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含二苯甲酮的磷脂酰胆碱类似物的合成。
DOI：
10.1021/jo030329d
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Spencer,ThomasA
中科院分区：
文献类型：
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作者：
Wang,Pingzhen;Blank,DavidH;Spencer,ThomasA
作为胆固醇和磷脂的细胞外排的合作研究的一部分，合成了在胆碱部分和C2和C1烷基链末端具有二苯甲酮基团的磷脂酰胆碱（PC）的光活化类似物4 − 8。描述了通过Suzuki偶联适当的长链含二苯甲酮的羧酸和醇的有效制备，以及通过调整已知方法将其掺入酰基和醚连接的PC类似物6 − 8。还描述了放射性标记这些PC类似物的方法的开发，通过在改性侧链中的双键的氢化。
As part of a collaborative study of cellular efflux of cholesterol and phospholipids, photoactivable analogues4−8of phosphatidylcholine (PC) having benzophenone groups in the choline moiety and at the end of the C2 and C1 alkyl chains have been synthesized. The efficient preparation via Suzuki coupling of the appropriate long-chain benzophenone-containing carboxylic acid and alcohol and their incorporation by adaptation of known approaches into the acyl- and ether-linked PC analogues6−8are described. Development of a method for radiolabeling these PC analogues, via hydrogenation of a double bond in modified side chains, is also described.