Cognitive rehabilitation interventions for executive function: Moving from bench to bedside in patients with traumatic brain injury
Cognitive rehabilitation interventions for executive function: Moving from bench to bedside in patients with traumatic brain injury
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DOI：
10.1162/jocn.2006.18.7.1212
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发表时间：
2006-07-01
影响因子：
3.2
通讯作者：
Whyte, John
中科院分区：
文献类型：
--
作者：
Cicerone, Keith;Levin, Harvey;Whyte, John
由前额驱动的分布式网络介导的执行功能经常因弥漫性轴索损伤和局灶性病变导致的创伤性脑损伤（TBI）而受损。除了计划和工作记忆等执行认知功能外，TBI的影响还影响社会认知和动机过程。为了鼓励应用认知神经科学的方法来研究脑外伤的恢复，相关的功能重组和干预措施的发展，本文回顾了脑外伤的病理生理学，批评了目前采用的执行功能评估方法，并评估了有前途的干预措施，反映了认知神经科学的进步。脑成像，以确定神经机制介导的执行功能障碍和响应TBI后的干预措施进行了讨论。
Executive function mediated by prefrontally driven distributed networks is frequently impaired by traumatic brain injury (TBI) as a result of diffuse axonal injury and focal lesions. In addition to executive cognitive functions such as planning and working memory, the effects of TBI impact social cognition and motivation processes. To encourage application of cognitive neuroscience methods to studying recovery from TBI, associated reorganization of function, and development of interventions, this article reviews the pathophysiology of TBI, critiques currently employed methods of assessing executive function, and evaluates promising interventions that reflect advances in cognitive neuroscience. Brain imaging to identify neural mechanisms mediating executive dysfunction and response to interventions following TBI is also discussed.