SUSCEPTIBILITY OF CAMPYLOBACTER ISOLATES TO THE BACTERICIDAL ACTIVITY OF HUMAN-SERUM
SUSCEPTIBILITY OF CAMPYLOBACTER ISOLATES TO THE BACTERICIDAL ACTIVITY OF HUMAN-SERUM
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DOI：
10.1093/infdis/151.2.227
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发表时间：
1985-01-01
影响因子：
6.4
通讯作者：
KOHLER, PF
中科院分区：
文献类型：
--
作者：
BLASER, MJ;SMITH, PF;KOHLER, PF
虽然C.空肠和相关的嗜热微生物是比C.胎儿，大多数血液或全身分离物是C。胎儿为了了解与此观察结果相关的病理生理学，对正常人血清中C。coli、C. jejuni和C.对粪便和血液中的胎儿分离株进行了研究。在标准化测定中，15 C.空肠和相关的分离株显示90%的杀灭率（平均90.6% ± 0.001）。5.9）;在更严格的条件下，相对抗性菌株被完全杀死。全是C。胎儿菌株在标准和严格条件下具有高度血清抗性。杀死C。通过将血清加热至56 ℃消融空肠。C，但通过补充补体而恢复。经典和替代补体途径都可能有助于杀伤，吸附研究证明了抗体依赖性。血清抵抗可使C.胎儿，而补体和抗体介导的血清敏感性的C。空肠可能是系统性侵犯相对较少的原因。
Although C. jejuni and related thermophilic organisms are more common human pathogens than are C. fetus, most bloodstream or systemic isolates are C. fetus. To understand the pathophysiology related to this observation, susceptibility to the bactericidal activity of normal human serum of C. coli, C. jejuni, and C. fetus isolates from feces and blood was studied. In standardized assays, 10 of 15 C. jejuni and related isolates showed 90% kill (mean, 90.6% .+-. 5.9); under more stringent conditions, the relatively resistant strains were completely killed. All C. fetus strains were highly serum resistant under standard and stringent conditions. Killing of C. jejuni was ablated by heating serum to 56.degree. C but restored by addition of complement. Both classical and alternative complement pathways may contribute to killing, and adsorption studies demonstrated antibody dependence. Serum resistance may permit systemic infection by C. fetus, whereas complement- and antibody-mediated serum sensitivity of C. jejuni may account for the relative infrequency of systemic invasion.