Functionalization of Colloids with Robust Inorganic-Based Lipid Coatings
Functionalization of Colloids with Robust Inorganic-Based Lipid Coatings
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DOI：
10.1021/ma048706r
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发表时间：
2004-12
期刊：
影响因子：
5.5
通讯作者：
Kiyofumi Katagiri;F. Caruso
中科院分区：
文献类型：
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作者：
Kiyofumi Katagiri;F. Caruso
通过自组装过程制备了核壳胶体，即包覆有聚乙烯（PE）多层膜和脂质双层膜的粒子。通过聚二烯丙基二甲基氯化铵（PDDA）和聚4-苯乙烯磺酸钠（PSS）在胶体颗粒上的层层组装制备了聚乙烯多层膜。无机基合成脂质，N-[N-（3-三乙氧基甲硅烷基）丙基琥珀酰氨基]双十六烷基胺（Si-脂质），用于膜的形成，并通过静电相互作用沉积到PE涂层的颗粒上。天然存在的脂质，二肉豆蔻酰磷脂酸钠盐（DMPA），也用于比较。通过微电泳逐步监测颗粒上的多层膜积聚，并通过荧光显微镜以及扫描和透射电子显微镜确认脂质双层的形成。硅脂质膜和DMPA膜对表面活性剂Triton X-100和乙醇的形态稳定性均较好。
Core−shell colloids, particles covered with polyelectrolyte (PE) multilayer films and lipid bilayer membranes, were prepared through self-assembly processes. The PE multilayer films were fabricated by the layer-by-layer (LbL) assembly of poly(diallyldimethylammonium chloride) (PDDA) and poly(sodium 4-styrenesulfonate) (PSS) onto colloidal particles. The inorganic-based synthetic lipid, N-[N-(3-triethoxysilyl)propylsuccinamoyl]dihexadecylamine (Si-lipid), was employed for membrane formation and was deposited onto the PE-coated particles through electrostatic interaction. The naturally occurring lipid, dimyristoylphosphatidic acid, sodium salt (DMPA), was also used for comparison. Multilayer film buildup on the particles was monitored stepwise by microelectrophoresis, and formation of the lipid bilayers was confirmed by fluorescence microscopy as well as scanning and transmission electron microscopy. The morphological stability of the Si-lipid and DMPA membranes to the surfactant Triton X-100 and ethanol wa...