HOMOCELLULAR REGULATORY MECHANISMS IN SODIUM-TRANSPORTING EPITHELIA - AVOIDANCE OF EXTINCTION BY FLUSH-THROUGH
HOMOCELLULAR REGULATORY MECHANISMS IN SODIUM-TRANSPORTING EPITHELIA - AVOIDANCE OF EXTINCTION BY FLUSH-THROUGH
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DOI：
10.1152/ajprenal.1981.241.6.f579
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发表时间：
1981-01-01
影响因子：
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通讯作者：
SCHULTZ, SG
中科院分区：
文献类型：
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作者：
SCHULTZ, SG
近年来，对几种钠转运上皮细胞的电生理学研究揭示了两种“同源”(内在)调节机制，它们似乎保护吸收细胞免受钠和钾含量的显著变化的影响，以响应跨细胞钠转运速率的快速和广泛的生理变化。它们是：1)细胞内钠的活性与顶端(粘膜)膜的钠电导成反比关系，2)从细胞中排出穿过基底膜的钠的速率(“泵活性”)和该屏障对钾的电导之间的平行关系。这篇综述的目的是记录这些血细胞调节机制，讨论它们的生理意义，并推测可能的潜在机制(S)。
In recent years electrophysiologic studies on several sodium-transporting epithelia have uncovered two “homocellular” (intrinsic) regulatory mechanisms that appear to protect the absorptive cells from marked changes in sodium and potassium content in response to rapid and wide-ranging physiologic variations in the rate of transcellular sodium transport. These are: 1) an inverse relation between intracellular sodium activity and the sodium conductance of the apical (mucosal) membrane, and 2) a parallel relation between the rate of sodium extrusion from the cell across the basolateral membrane (“pump activity”) and the conductance of that barrier to potassium. The purpose of this review is to document these homocellular regulatory mechanisms, discuss their physiologic significance, and speculate on possible underlying mechanism(s).