Paroxetine and amitriptyline in the treatment of depression in general practice
Paroxetine and amitriptyline in the treatment of depression in general practice
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DOI：
10.1111/j.1600-0447.1996.tb10623.x
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发表时间：
1996-03-01
影响因子：
6.7
通讯作者：
Nilsson, J
中科院分区：
文献类型：
--
作者：
Christiansen, PE;Behnke, K;Nilsson, J
帕罗西汀与阿米替林的为期 8 周的双盲、随机、多中心、对照、平行组比较纳入了丹麦全科诊所的 144 名门诊患者，年龄为 18-65 岁，诊断为抑郁症且 HAMD-17 评分为 15 分或以上。该研究的目的主要是评估治疗的疗效和耐受性。此外，还关注体重变化和主观幸福感。疗效结果显示两种药物效果相当。然而，帕罗西汀的耐受性优于阿米替林，并且当从分析中剔除四名不可评估的患者时，这种差异达到显着水平。此外，阿米替林组的体重显着增加，而帕罗西汀组的体重没有显着变化。通过VAS测量的主观幸福感在各组之间没有差异。总之，帕罗西汀是一种有效且耐受性良好的抗抑郁药，非常适合在一般实践中治疗抑郁症。
A total of 144 outpatients in general practice in Denmark, aged 18-65 years and diagnosed as suffering from depression with a HAMD-17 score of 15 or more, were included in this 8-week double-blind, randomised, multicentre, controlled, parallel group comparison of paroxetine versus amitriptyline. The purpose of the study was primarily to evaluate efficacy and tolerance of treatment. In addition, focus was added on weight change and subjective well-being. The efficacy results showed equal effect of both drugs. However, paroxetine was tolerated better than amitriptyline, and this difference reached the level of significance when four non-evaluable patients were taken out of the analysis. Moreover, there was a significant weight increase in the amitriptyline group and no significant weight change in the paroxetine group. There was no difference between the groups as regards subjective well-being as measured by the VAS. In conclusion, paroxetine is an effective and well-tolerated antidepressant, and well-suited for the treatment of depression in general practice.