Dementia and mortality in persons with Down's syndrome
Dementia and mortality in persons with Down's syndrome
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DOI：
10.1111/j.1365-2788.2006.00842.x
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发表时间：
2006-10-01
影响因子：
3.6
通讯作者：
van Duijin, C.
中科院分区：
文献类型：
--
作者：
Coppus, A.;Evenhuis, H.;van Duijin, C.
背景：大量研究表明，唐氏综合征（DS）患者患阿尔茨海默病（AD）的风险增加。然而，目前还不清楚是否所有的人与DS将发展成痴呆，因为他们达到老年期。方法：我们研究了506人与DS，年龄在45岁及以上。每年重复进行认知、功能和身体状况的标准化评估。如果出现恶化，则对患者进行检查，并根据修订的荷兰共识方案和ICD-10精神障碍症状检查表进行痴呆的鉴别诊断。我们将我们的研究结果与文献中的报道进行了比较。结果：痴呆的总患病率为16.8%。在60岁之前，痴呆症的患病率每隔5年翻一番。49岁以下的患病率为8.9%，50 ~ 54岁的患病率为17.7%，55 ~ 59岁的患病率为32.1%。在60岁及以上的年龄组中，痴呆症的患病率略有下降，降至25.6%。60岁以后没有增加的原因可能是老年痴呆症患者（44.4%）的死亡率高于我们在3.3年随访期间观察到的非痴呆症患者（10.7%）。60岁及以上年龄组的痴呆症发病率没有下降。我们的研究结果与文献中发表的结果非常相似。痴呆患者更常接受抗癫痫、抗精神病和抗抑郁药物治疗。抑郁症的历史是密切相关的dementions.Conclusions：我们的研究是迄今为止最大的人群为基础的研究之一。我们发现，尽管随着年龄的增长，患病率呈指数级增长，老年痴呆症患者的患病率不高于25.6%。
Background: Numerous studies have documented that persons with Down's syndrome (DS) are at an increased risk of Alzheimer's disease (AD). However, at present it is still not clear whether or not all persons with DS will develop dementia as they reach old age.Methods: We studied 506 people with DS, aged 45 years and above. A standardized assessment of cognitive, functional and physical status was repeated annually. If deterioration occurred, the patients were examined and the differential diagnosis of dementia was made according to the revised Dutch consensus protocol and according to the ICD-10 Symptom Checklist for Mental Disorders. We compared our findings with those reported in the literature.Results: The overall prevalence of dementia was 16.8%. Up to the age of 60, the prevalence of dementia doubled with each 5-year interval. Up to the age of 49, the prevalence is 8.9%, from 50 to 54, it is 17.7%, and from 55 to 59, it is 32.1%. In the age category of 60 and above, there is a small decrease in prevalence of dementia to 25.6%. The lack of increase after the age of 60 may be explained by the increased mortality among elderly demented DS patients (44.4%) in comparison with non-demented patients (10.7%) who we observed during a 3.3-year follow-up. There was no decrease in incidence of dementia in the age group of 60 and above. Our findings are very similar to those published in the literature. Patients with dementia were more frequently treated with antiepileptic, antipsychotic and antidepressant drugs. The history of depression was strongly associated with dementia.Conclusions: Our study is one of the largest population-based studies to date. We found that despite the exponential increase in prevalence with age, the prevalence of dementia in the oldest persons with DS was not higher than 25.6%.