Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities.
Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities.
复制标题
DOI：
10.1038/s41598-021-90035-7
复制
发表时间：
2021-05-18
影响因子：
4.6
通讯作者：
Cao S
中科院分区：
文献类型：
--
作者：
Yuan G;Guan Y;Yi H;Lai S;Sun Y;Cao S
抗生素耐药性严重威胁人类健康，迫切需要新的抗菌药物。黄酮类化合物作为植物次生代谢产物中最大的一类，广泛存在于植物的各个部位，其抑菌活性日益受到人们的关注。根据已报道的66个黄酮类化合物的理化参数和抑菌活性，建立了它们的ACD/LogP或LogD 7.40与它们对革兰氏阳性菌的最低抑菌浓度（MIC）的回归方程，相关系数均在0.93以上，并用另外68个黄酮类化合物进行了验证。根据这两个方程，大多数黄酮类化合物对革兰氏阳性菌的MIC可以从它们的ACD/LogP或LogD 7.40粗略计算，并且预测最小MIC约为10.2或4.8 μM，更可能福尔斯落入2.6至10.2 μM或1.2至4.8 μM的范围内。同时，两种倾向性凹回归曲线表明亲脂性是黄酮类化合物抗革兰氏阳性菌的关键因素。结合文献分析，结果还表明，黄酮类化合物作用于革兰氏阳性菌的主要部位是细胞膜，可能涉及磷脂双分子层的损伤、呼吸链或ATP合成的抑制等。
Antimicrobial resistance seriously threatened human health, and new antimicrobial agents are desperately needed. As one of the largest classes of plant secondary metabolite, flavonoids can be widely found in various parts of the plant, and their antibacterial activities have been increasingly paid attention to. Based on the physicochemical parameters and antibacterial activities of sixty-six flavonoids reported, two regression equations between their ACD/LogP or LogD7.40 and their minimum inhibitory concentrations (MICs) to gram-positive bacteria were established with the correlation coefficients above 0.93, and then were verified by another sixty-eight flavonoids reported. From these two equations, the MICs of most flavonoids against gram-positive bacteria could be roughly calculated from their ACD/LogP or LogD7.40, and the minimum MIC was predicted as approximately 10.2 or 4.8 μM, more likely falls into the range from 2.6 to 10.2 μM, or from 1.2 to 4.8 μM. Simultaneously, both tendentiously concave regression curves indicated that the lipophilicity is a key factor for flavonoids against gram-positive bacteria. Combined with the literature analyses, the results also suggested that the cell membrane is the main site of flavonoids acting on gram-positive bacteria, and which likely involves the damage of phospholipid bilayers, the inhibition of the respiratory chain or the ATP synthesis, or some others.
登录
查看更多内容
影响因子：
2.6
作者：
Singh, Salam Pradeep;Konwarh, Rocktotpal;Karak, Niranjan
通讯作者：
Karak, Niranjan
影响因子：
5.8
作者：
LEBRUN, PPH;FOX, PLA;BODDE, HE
通讯作者：
BODDE, HE
影响因子：
6.3
作者：
Kurosu M;Siricilla S;Mitachi K
通讯作者：
Mitachi K
影响因子：
5.2
作者：
Matsumoto Y;Kaihatsu K;Nishino K;Ogawa M;Kato N;Yamaguchi A
通讯作者：
Yamaguchi A
影响因子：
15
作者：
HANSCH, C;FUJITA, T
通讯作者：
FUJITA, T