Heart rate variability in patients with allergic rhinitis
Heart rate variability in patients with allergic rhinitis
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DOI：
10.7205/milmed.172.1.98
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发表时间：
2007-01-01
影响因子：
1.2
通讯作者：
Isik, Ersoy
中科院分区：
文献类型：
--
作者：
Yokusoglu, Mehmet;Ozturk, Sami;Isik, Ersoy
考虑到自主神经失衡在超敏反应发病机制中的作用，我们通过对变应性鼻炎患者心率变异性(HRV)的时间域分析来评估自主神经系统。24例变应性鼻炎患者和22例健康体检者(平均年龄分别为41.8岁和37+/-9岁)进入研究。过敏性鼻炎的诊断是基于病史、症状和皮肤点刺试验结果。获得24小时动态心电记录，并分析其时间域指标。心率变异性分析显示，正常RR间期的SD、正常周期连续差值的SD和HRV三角指数在两组间无显著差异，但研究组的均方根连续差值、RR间期超过50毫秒的个数、相邻正常RR间期超过50毫秒的百分比差值明显大于对照组。我们的研究结果表明，预测副交感神经优势的HRV指数在变应性鼻炎患者中升高。这一发现表明，迷走神经的激活不仅存在于鼻子中，还存在于其他系统中，包括心血管系统。
Considering the role of autonomic imbalance in the pathogenesis of hypersensitivity reactions, we evaluated the autonomic system through time-domain analysis of heart rate variability (HRV) in patients with allergic rhinitis. Twenty-four patients with allergic rhinitis and 22 healthy subjects (mean age, 41 8 years and 37 +/- 9 years, respectively) were enrolled in the study. The diagnosis of allergic rhinitis was based on the history, symptoms, and skin prick tests results. Twenty-four-hour ambulatory electrocardiographic recordings were obtained, and the time-domain indices were analyzed. Analysis of HRV revealed that the SD of normal RR intervals, SD of successive differences in normal cycles, and HRV triangular index were not significantly different between the groups, but the root mean square successive difference, number of RR intervals exceeding 50 milliseconds, and percentage difference between adjacent normal RR intervals exceeding >50 milliseconds were significantly greater in the study group, compared with the control group. Our findings showed that HRV indices, which predict parasympathetic predominance, were increased in patients with allergic rhinitis. This finding shows that vagal activation is present not only in the nose but also in other systems, including the cardiovascular system.