RETINAL GANGLION-CELL DEGENERATION IN ALZHEIMERS-DISEASE
RETINAL GANGLION-CELL DEGENERATION IN ALZHEIMERS-DISEASE
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DOI：
10.1016/0006-8993(89)90653-7
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发表时间：
1989-11-06
期刊：
影响因子：
2.9
通讯作者：
MILLER, CA
中科院分区：
文献类型：
--
作者：
BLANKS, JC;HINTON, DR;MILLER, CA
本研究记录了阿尔茨海默病（AD）患者视网膜神经节细胞变性的光镜和超微结构特征。结果显示视网膜神经节细胞（RGC）的变性，其特征在于细胞质的空泡化、“泡沫状”外观。这种变性在AD中是独特的，因为在检查的任何病例中，RGCs内没有神经纤维缠结，或者视网膜或视神经中没有神经炎性斑块或淀粉样血管病。这些结果表明，神经节细胞层（GCL）的神经元变性应添加到阿尔茨海默病患者的神经病理学变化的星座。
This study documents the light-microscopic and ultrastructural characteristics of ganglion cell degeneration in the retinas of patients with Alzheimer''s disease (AD). The results show degeneration in the retinal ganglion cells (RGCs) characterized by a vacuolated, ''frothy'' appearance of the cytoplasm. The degeneration is unique in AD because of the absence of neurofibrillary tangles within the RGCs, or of neuritic plaques or amyloid angiopathy in the retinas or optic nerves of any of the cases examined. These results suggest that neuronal degeneration in the ganglion cell layer (GCL) should be added to the constellation of neuropathologic changes found in patients with Alzheimer''s disease.