Mid-Thigh Cortical Bone Structural Parameters, Muscle Mass and Strength, and Association with Lower Limb Fractures in Older Men and Women (AGES-Reykjavik Study)
Mid-Thigh Cortical Bone Structural Parameters, Muscle Mass and Strength, and Association with Lower Limb Fractures in Older Men and Women (AGES-Reykjavik Study)
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DOI：
10.1007/s00223-012-9585-6
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发表时间：
2012-05-01
影响因子：
4.2
通讯作者：
Sigurdsson, Gunnar
中科院分区：
文献类型：
--
作者：
Johannesdottir, Fjola;Aspelund, Thor;Sigurdsson, Gunnar
在一项横断面研究中，我们使用通过大腿中部的单轴计算机断层扫描数据调查了老年人大腿中部肌肉和骨骼参数之间的关系。此外，我们研究了这些变量与低创伤性下肢骨折的关系。共有3762名年龄在66-96岁之间的老年人（1838名男性和1924名女性）参与了雷克雅未克老年研究。总横截肌面积和膝关节伸肌力量随年龄的增长而下降，男女相似。肌肉参数与皮质面积和总轴面积（根据年龄、身高和体重调整）相关性最强，但对这些骨骼参数的变异性的解释< 10%。髓质面积（MA）和屈曲比（BR）随年龄的增长，女性几乎是男性的4倍。MA与肌肉参数之间的相关性不显著。在平均5.3年的随访期间，113名女性和66名男性发生了下肢骨折。小肌肉面积、低膝关节伸肌力量、大MA、低皮质厚度和高BR与两性骨折显著相关。我们的研究结果表明，骨骼和肌肉的流失速度和性别模式不同。
In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924 women), aged 66-96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical area and total shaft area (adjusted for age, height, and weight) but explained < 10 % of variability in those bone parameters. The increment in medullary area (MA) and buckling ratio (BR) with age was almost fourfold greater in women than men. The association between MA and muscle parameters was nonsignificant. During a median follow-up of 5.3 years, 113 women and 66 men sustained incident lower limb fractures. Small muscular area, low knee extensor strength, large MA, low cortical thickness, and high BR were significantly associated with fractures in both sexes. Our results show that bone and muscle loss proceed at different rates and with different gender patterns.