Elucidating neural network functional connectivity abnormalities in bipolar disorder: toward a harmonized methodological approach.
Elucidating neural network functional connectivity abnormalities in bipolar disorder: toward a harmonized methodological approach.
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DOI：
10.1016/j.bpsc.2015.12.006
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Phillips ML
中科院分区：
文献类型：
--
作者：
Chase HW;Phillips ML
双相情感障碍（BD）是一种以情绪不稳定和调节障碍为特征的心境障碍，与功能连接的改变有关，特别是使用功能性MRI评估。在这里，我们提供了一个现存文献的概述，并在其中出现的主题。我们确定了已发表的研究描述功能连接在BD使用PubMed和后续搜索。最一致的证据支持杏仁核和腹侧前额叶皮层（PFC）的侧区之间的功能连接异常增强，无论是在休息还是情绪处理期间。杏仁核和内侧PFC区域之间的相互作用改变与BD有关，但与核心症状的相关性较低，有时与情绪状态或精神病有关。据报道，内侧和外侧腹侧PFC之间的相互作用在BD中也发生了改变，并可能介导杏仁核/vlPFC连接的估计。我们还描述了其他主题，包括一个新兴的文学研究奖励电路，这突出了腹侧纹状体和内侧前额叶皮质之间的异常功能的相互作用，以及检查全球网络异常的BD的出现。BD的功能连接研究已经建立了PFC和杏仁核之间的相互作用改变。为了解决文献中的不一致之处，我们建议通过大规模的途径，和基于网络的连接分析，结构连接的整合和确认功能连接的动态和上下文相关的变化，作为澄清异常神经回路的障碍。
Bipolar disorder (BD), a mood disorder characterized by emotional lability and dysregulation, is associated with alterations in functional connectivity, particularly as assessed using functional MRI. Here, we provide an overview of the extant literature, and themes that have emerged within it. We identified published research describing functional connectivity in BD using PubMed and follow-up searches. The most consistent evidence favors abnormally heightened functional connectivity between the amygdala and the lateral regions of the ventral prefrontal cortex (PFC), both during rest or emotional processing. Altered interactions between the amygdala and more medial PFC regions have been implicated in BD, but are less consistently related to core symptoms and are sometimes associated with mood state or psychosis. Interactions between medial and lateral ventral PFC have also been reported to be altered in BD, and may mediate estimates of amygdala/vlPFC connectivity. We also describe other themes, including an emerging literature examining reward circuitry, which has highlighted abnormal functional interactions between the ventral striatum and medial prefrontal cortex, as well as the advent of examining global network abnormalities in BD. Functional connectivity studies in BD have established altered interactions between PFC and the amygdala. To address the inconsistencies in the literature, we suggest avenues for the adoption of large scale, and network-based analysis of connectivity, the integration of structural connectivity and the acknowledgement of dynamic and context-related shifts in functional connectivity as a means of clarifying the abnormal neural circuitry in the disorder.