Late-life depression and mortality: influence of gender and antidepressant use
Late-life depression and mortality: influence of gender and antidepressant use
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DOI：
10.1192/bjp.bp.107.039164
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发表时间：
2008-01-01
影响因子：
10.5
通讯作者：
Ancelin, Marie-Laure
中科院分区：
文献类型：
--
作者：
Ryan, Joanne;Carriere, Isabelle;Ancelin, Marie-Laure
背景抑郁症可能会增加某些老年人亚群的死亡风险，但抗抑郁药在这种联系中所起的作用尚未得到彻底的探讨。方法采用调整后的考克斯比例风险模型来确定抑郁症和/或抑郁症之间的关系。或抗抑郁药的使用和4年生存率的7363社区居住的老年人。重度抑郁症进行了评估，使用标准化的精神病学检查的基础上，DSM-IV标准和抑郁症状进行了评估，使用中心流行病学研究，抑郁scale.ResultsDepressed抑郁症的男性使用抗抑郁药的死亡风险最大，抑郁症的严重程度增加相应的更高的危险风险。在妇女中，只有严重的抑郁症，在没有治疗显着相关mortality.ConclusionsThe抑郁症和死亡率之间的关联是性别依赖性的，并根据症状负荷和抗抑郁药的使用。
BackgroundDepression may increase the risk of mortality among certain subgroups of older people, but the part played by antidepressants in this association has not been thoroughly explored.AimsTo identify the characteristics of older populations who are most at risk of dying, as a function of depressive symptoms, gender and antidepressant use.MethodAdjusted Cox proportional hazards models were used to determine the association between depression and/or antidepressant use and 4-year survival of 7363 community-dwelling elderly people. Major depressive disorder was evaluated using a standardised psychiatric examination based on DSM-IV criteria and depressive symptoms were assessed using the Center for Epidemiological Studies-Depression scale.ResultsDepressed men using antidepressants had the greatest risk of dying, with increasing depression severity corresponding to a higher hazard risk. Among women, only severe depression in the absence of treatment was significantly associated with mortality.ConclusionsThe association between depression and mortality is gender-dependent and varies according to symptom load and antidepressant use.Declaration of interestNone.