Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient.
Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient.
复制标题
先天网络：血栓性微血管病，凝血和补体在敏化肾脏移植受体中的激活。
DOI：
10.1016/j.trre.2018.01.001
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Knechtle S
中科院分区：
文献类型：
--
作者：
Manook M;Kwun J;Sacks S;Dorling A;Mamode N;Knechtle S
Thrombotic microangiopathy (TMA) is a histological feature of antibody-mediated rejection and has the potential to cause problematic graft dysfunction, particularly for highly sensitized cross-match positive kidney transplant recipients. Prompt recognition of pertinent histopathological and systemic features of TMA in kidney transplantation is necessary. Underlying mechanisms of this process involve the activation of both complement and coagulation systems as a response to HLA antibody. As serine proteases, coagulation and complement cascades exhibit similar characteristics with respect to homeostatic function. Increasing evidence now exists for the interaction between these innate defenses in both activation and regulation, lending scope for intervention. Understanding the complexities of these interactions remains a challenge. This review provides an overview of the current understanding, particularly with respect to the activation of coagulation and complement by HLA antibody in the setting of highly sensitized kidney transplantation.
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DOI：
10.1111/ajt.13688
发表时间：
2016-06
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Burghuber CK;Kwun J;Page EJ;Manook M;Gibby AC;Leopardi FV;Song M;Farris AB 3rd;Hong JJ;Villinger F;Adams AB;Iwakoshi NN;Knechtle SJ
通讯作者：
Knechtle SJ
影响因子：
8.8
作者：
Ashman, N.;Chapagain, A.;Yaqoob, M. M.
通讯作者：
Yaqoob, M. M.
影响因子：
3.9
作者：
Ezzelarab, Mohamed;Ekser, Burcin;Cooper, David K. C.
通讯作者：
Cooper, David K. C.
影响因子：
0.9
作者：
Caires, R. A.;Marques, I. D. B.;David-Neto, E.
通讯作者：
David-Neto, E.
影响因子：
13.6
作者：
Chua, Jamie S.;Baelde, Hans J.;Cohen, Danielle
通讯作者：
Cohen, Danielle