A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus(2019-nCoV)Potentially Related to Viral Transmissibility
A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus(2019-nCoV)Potentially Related to Viral Transmissibility
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新型肺炎冠状病毒（2019-nCoV）刺突蛋白中预测的独特蛋白酶切割位点可能与病毒传播能力相关
DOI：
10.1007/s12250-020-00212-7
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发表时间：
2020
影响因子：
5.5
通讯作者：
Ge Xingyi
中科院分区：
文献类型：
--
作者：
Wang Qiong;Qiu Ye;Li Jinyan;Zhou Zhijian;Liao Ceheng;Ge Xingyi
2019年12月，一种新型人类冠状病毒在湖北武汉市引起重症肺炎(冠状病毒病2019，新冠肺炎)流行。至此，该病毒已蔓延到中国的所有地区，甚至其他国家。截至2020年2月14日，该病毒已在全球造成67,102例确诊感染，1,526例死亡。病毒感染潜伏期为2~14天，典型的临床症状为发热、干咳、呼吸困难、头痛和肺炎。发病可因肺泡损伤而导致进行性呼吸衰竭，甚至死亡(Chan等2020；Chen等人，2020；Huang等人，2020)。
In December 2019,a novel human coronavirus caused an epidemic of severe pneumonia(Coronavirus Disease 2019,COVID-19)in Wuhan,Hubei,China(Wu et al.2020;Zhu et al.2020).So far,this virus has spread to all areas of China and even to other countries.The epidemic has caused 67,102 confirmed infections with 1526 fatal cases worldwide by February 14th,2020.The viral infection incubation period varies from 2 to 14 days and typical clinical symptoms are fever,dry cough,dyspnea,headache,and pneumonia.Disease onset may result in progressive respiratory failure due to alveolar damage and even death(Chan et al.2020;Chen et al.2020;Huang et al.2020).