Mechanical and temperature stressor-induced seizure-and-paralysis behaviors in Drosophila bang-sensitive mutants.
Mechanical and temperature stressor-induced seizure-and-paralysis behaviors in Drosophila bang-sensitive mutants.
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DOI：
10.3109/01677063.2012.690011
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发表时间：
2012-06
影响因子：
1.9
通讯作者：
Wu CF
中科院分区：
文献类型：
--
作者：
Burg MG;Wu CF
果蝇的“Bang-sensitive”突变体在机械冲击下表现出明显的麻痹和瘫痪行为。我们发现，这里描述的每一个bang敏感突变体（bas，besides，eas和tko）在暴露于高温或低温时也表现出相似的行为特征。这些剧目是由穿插的癫痫发作和瘫痪的时期，似乎有有趣的相似之处与脊椎动物癫痫样行为。分析这些Bang-sensitive突变苍蝇的雌雄同体镶嵌表明，这两种类型的行为所需的解剖学病灶不完全重叠，因为它们是可分离的马赛克苍蝇。对马赛克和断头苍蝇的观察表明，所有或没有表达的麻痹和瘫痪行为，表明全球活动和神经系统中的长距离相互作用。因此，目前可用的果蝇bang敏感突变体的多样性集合可以作为突变和细胞分析的丰富来源，以确定负责癫痫发作表型的相互作用的分子网络。
“Bang-sensitive” mutants of Drosophila display characteristic repertoires of distinct seizure-and-paralysis behaviorsupon mechanical shock. We found that each of the bang-sensitive mutants described here (bas, bss, eas, and tko) also displayed similar behavioral repertoires upon exposure to either high or low temperature. These repertoires are composed of interspersed periods of seizure and paralysis, and appear to have interesting parallels with vertebrate epileptiform behavior. Analysis of gynandromorph mosaics of these bang-sensitive mutant flies indicated that anatomical foci required for these two types of behaviors do not totally overlap as they were separable among mosaic flies. Observations on mosaic and decapitated flies demonstrated an all-or-none expression of the seizure-and-paralysis behaviors, indicating global activity and long-range interactions in the nervous system. Therefore, the diverse collection of currently available Drosophila bang-sensitive mutants may serve as a rich source for mutational and cellular analysis to identify interacting molecular networks that are responsible for seizure phenotypes.