Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice.
Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice.
复制标题
共轭亚油酸可防止 C57BL/6 雌性小鼠与年龄相关的骨质流失。
DOI：
10.1016/j.jnutbio.2006.08.002
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Fernandes,Gabriel
中科院分区：
文献类型：
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作者：
Rahman,MdMizanur;Bhattacharya,Arunabh;Banu,Jameela;Fernandes,Gabriel
骨质疏松症是老年人发病的主要原因之一。炎症对骨转换有显著影响，诱发慢性骨质疏松症。膳食营养具有调节炎症反应的能力。因此，营养策略和生活方式的改变可以预防与年龄相关的骨质疏松症，从而提高老年人的生活质量。共轭亚油酸（CLA）已被证明对钙和骨代谢有积极影响。因此，本研究旨在探讨CLA对中年C57BL/6雌性小鼠骨密度（BMD）的影响。饲粮10周后，cla喂养的小鼠（14个月）在不同骨骼区域的骨密度均高于玉米油喂养的小鼠。骨密度升高伴随着促炎细胞因子（如肿瘤坏死因子α、白细胞介素-6和NF-κB配体受体激活剂）活性降低和破骨细胞功能下降。此外，与co喂养的小鼠相比，cla喂养的小鼠脂肪量显著减少，肌肉量显著增加。总之，这些发现表明CLA可能通过调节炎症标志物和破骨细胞因子来预防骨和肌肉质量的损失。
Osteoporosis is one of the major causes of morbidity in the elderly. Inflammation exerts a significant influence on bone turnover, inducing the chronic form of osteoporosis. Dietary nutrition has the capacity to modulate inflammatory response. Therefore, nutritional strategies and lifestyle changes may prevent age-related osteoporosis, thereby improving the quality of life of the elderly population. Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism. Hence, this study was undertaken to examine the effect of CLA on bone mineral density (BMD) in middle-aged C57BL/6 female mice. After 10 weeks on diet, CLA-fed mice (14 months) maintained a higher BMD in different bone regions than corn oil (CO)-fed mice. The increased BMD was accompanied by a decreased activity of proinflammatory cytokines (such as tumor necrosis factor α, interleukin-6 and the receptor activator of NF-κB ligand) and decreased osteoclast function. Furthermore, a significant decrease in fat mass and an increase in muscle mass were also observed in CLA-fed mice compared to CO-fed mice. In conclusion, these findings suggest that CLA may prevent the loss of bone and muscle mass by modulating markers of inflammation and osteoclastogenic factors.