Breast cancer cells cultured in a system of new design presecrete an extracellular matrix and proliferate within it without cell-cell adhesion.
Breast cancer cells cultured in a system of new design presecrete an extracellular matrix and proliferate within it without cell-cell adhesion.
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在新设计的系统中培养的乳腺癌细胞预先分泌细胞外基质并在其中增殖，而无需细胞与细胞粘附。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
M. Osborne
中科院分区：
文献类型：
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作者：
J. Fishman;A. González;M. Osborne
乳腺癌细胞MCF-7系在微孔、疏水性聚合物管中培养时，会预先分泌带状、纱布状的细胞外基质，然后它们在其中驻留和增殖，而没有可观察到的细胞-细胞粘附，并且可以在培养基中完全没有血清补充的情况下进行增殖。这种细胞功能归因于氧气直接进入细胞附着位点。
Breast cancer cells, MCF-7 line, when cultured in microporous, hydrophobic polymer tubes, presecrete ribbon shaped, gauze-like extracellular matrices within which they then reside and proliferate without observable cell-cell adhesion and can do so in the complete absence of serum supplement in the culture media. This cell functioning is attributed to the direct access of oxygen to the cell attachment site.